Sensitivity of Escherichia coli to proline analogues during osmotic stress and anaerobiosis
Sensitivity of Escherichia coli to proline analogues during osmotic stress and anaerobiosis
复制标题
渗透压和厌氧过程中大肠杆菌对脯氨酸类似物的敏感性
DOI：
10.1111/j.1472-765x.1996.tb01143.x
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发表时间：
1996
影响因子：
2.4
通讯作者：
C. Deutch
中科院分区：
文献类型：
--
作者：
L.M. Reese;K. Cutler;C. Deutch
L.M.里斯，K.O.卡特勒和 C.E. 多奇。 1996. 在有氧和厌氧条件下，在含有浓度不断增加的 NaCl 的培养物中测定了野生型大肠杆菌 K-12 对一系列脯氨酸类似物的敏感性。细菌对 L-氮杂环丁烷-2-羧酸盐和 L-噻唑烷-4-羧酸盐最敏感。这些化合物的最低抑制浓度在渗透胁迫期间逐渐降低，但细菌在有氧条件下比厌氧条件下对这些脯氨酸类似物更敏感。厌氧条件下灵敏度的降低并不反映培养基中化合物的降解。由于尿液和髓质肾组织都含有相对较低的氧浓度，这些结果引起了人们对脯氨酸或甘氨酸甜菜碱类似物在治疗尿路感染中的潜在用途的怀疑。
L.M. REESE, K.O. CUTLER AND C.E. DEUTCH. 1996. The sensitivity of wild‐type Escherichia coli K‐12 to a series of proline analogues was determined in cultures containing increasing concentrations of NaCl under both aerobic and anaerobic conditions. The bacteria were most sensitive to L‐azetidine‐2–carboxylate and L‐thiazolidine‐4–carboxylate. The minimum inhibitory concentrations for these compounds decreased progressively during osmotic stress, but the bacteria were much more sensitive to these proline analogues under aerobic conditions than during anaerobiosis. The reduced sensitivity under anaerobic conditions did not reflect degradation of the compounds in the culture medium. Since both urine and medullary renal tissue contain relatively low oxygen concentrations, these results raise doubts about the potential use of proline or glycine betaine analogues in treating urinary tract infections.