Synthetic approaches to understanding biological constraints.
Synthetic approaches to understanding biological constraints.
复制标题
理解生物限制的综合方法。
DOI：
10.1016/j.cbpa.2012.05.199
复制
发表时间：
2012
影响因子：
7.8
通讯作者：
Gore,Jeff
中科院分区：
文献类型：
--
作者：
Velenich,Andrea;Gore,Jeff
微生物可以很容易地培养，它们的基因组可以很容易地操纵。由于这些原因，单细胞生物的实验室系统越来越多地用于开发和测试有关生物约束的理论，这些约束表现在生物组织的不同层次，从最佳基因表达水平到复杂的个人和社会行为。生物学约束的定量描述最近在几个领域取得了进展，例如制定管理细胞整个经济的全球法律，直接实验测量导致最佳基因表达的权衡，描述自然发生的健身景观，以及对稳定细菌生态系统的要求。
Microbes can be readily cultured and their genomes can be easily manipulated. For these reasons, laboratory systems of unicellular organisms are increasingly used to develop and test theories about biological constraints, which manifest themselves at different levels of biological organization, from optimal gene-expression levels to complex individual and social behaviors. The quantitative description of biological constraints has recently advanced in several areas, such as the formulation of global laws governing the entire economy of a cell, the direct experimental measurement of the trade-offs leading to optimal gene expression, the description of naturally occurring fitness landscapes, and the appreciation of the requirements for a stable bacterial ecosystem.