Dynamic programing of CD8+ T cell trafficking after live viral immunization
Dynamic programing of CD8+ T cell trafficking after live viral immunization
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DOI：
10.1016/j.immuni.2006.06.019
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发表时间：
2006-09-01
期刊：
影响因子：
32.4
通讯作者：
Kupper, Thomas S.
中科院分区：
文献类型：
--
作者：
Liu, Luzheng;Fuhlbrigge, Robert C.;Kupper, Thomas S.
病毒感染后，无论感染途径如何，激活的T细胞都存在于多种组织中。这些细胞是如何获得多效性归巢能力的尚不清楚。通过使用皮肤痘苗病毒感染模型，我们证明了T细胞运输的调节是多阶段的。在完成三次细胞分裂后，CD8(+)T细胞上调了引流淋巴结(LN)内特定的皮肤归巢分子。在感染后60小时，一些活化的T细胞到达感染组织，而另一些则进入远处的无抗原LN。在这种新的环境中，这些后一种细胞继续分裂并获得额外的组织归巢分子，而不依赖于抗原提呈。病毒清除后，最初的皮肤归巢印记成为记忆细胞上的主要归巢表型，并提供了针对二次皮肤挑战的卓越保护。这些观察证明了T细胞在病原体进入部位提供即时组织特异性免疫控制和更灵活的系统保护以防止病原体传播的机制。
After viral infection, activated T cells are present in multiple tissues regardless of the infection route. How these cells acquire pleiotropic homing ability is unclear. By using a cutaneous vaccinia virus infection model, we demonstrate that regulation of T cell trafficking is multiphasic. Upon completion of three cell divisions, CD8(+) T cells upregulated specific skin-homing molecules within draining lymph nodes (LN). By 60 hr after infection, some activated T cells reached the infected tissue, while others entered distant antigen-free LN. These latter cells continued to divide and acquire additional tissue-homing molecules in this new setting, independent of antigen presentation. After viral clearance, the initial skin-homing imprint became the predominant homing phenotype on memory cells and provided superior protection against secondary cutaneous challenge. These observations demonstrate a mechanism by which T cells provide both immediate tissue-specific immune control at the pathogen entry site and a more flexible systemic protection against pathogen dissemination.