A Prospective, Multicenter Survey on Causes of Chronic Cough in China
A Prospective, Multicenter Survey on Causes of Chronic Cough in China
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中国慢性咳嗽病因的前瞻性、多中心调查
DOI：
10.1378/chest.12-0441
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发表时间：
2013-03-01
期刊：
影响因子：
9.6
通讯作者：
Zhong, Nanshan
中科院分区：
文献类型：
--
作者：
Lai, Kefang;Chen, Ruchong;Zhong, Nanshan
背景：中国慢性咳嗽的病因及其与地理、季节、年龄和性别的关系在很大程度上不确定。方法：采用改进的诊断算法对中国五个地区的慢性咳嗽患者进行前瞻性、多中心调查。调查了地理、季节、年龄和性别对慢性咳嗽谱的影响。结果：本研究共纳入704例成人患者，其中男性315例（44.7%），女性389例（55.3%）。640例（90.9%）确定了慢性咳嗽的病因。常见病因包括咳嗽变异性哮喘（CVA）（32.6%）、上呼吸道咳嗽综合征（UACS）（18.6%）、嗜酸性支气管炎（EB）（17.2%）和特应性咳嗽（AC）（13.2%）。总体而言，这4个原因在5个不同地区的占比为75.2% ~ 87.6%，但差异不显著（P < 0.05），尽管单个原因存在差异。胃食管反流引起的咳嗽占4.6%。季节性、性别和年龄与慢性咳嗽谱无关（P < 0.05）。结论：CVA、UACS、EB和AC是中国慢性咳嗽的常见病因。地理、季节、年龄和性别与慢性咳嗽谱系无关。胸部2013;143 (3): 613 - 620
Background: The causes of chronic cough in China and its relations with geography, seasonality, age, and sex are largely uncertain.Methods: A prospective, multicenter survey was conducted to evaluate patients with chronic cough across five regions in China by using a modified diagnostic algorithm. The effects of geography, seasonality, age, and sex on spectrum of chronic cough were also investigated.Results: The current study evaluated 704 adult patients, including 315 men (44.7%) and 389 women (55.3%). The causes of chronic cough were determined in 640 subjects (90.9%). Common causes included cough variant asthma (CVA) (32.6%), upper airway cough syndrome (UACS) (18.6%), eosinophilic bronchitis (EB) (17.2%), and atopic cough (AC) (13.2%). Collectively, these four causes accounted for 75.2% to 87.6% across five different regions without significant difference (P>.05), although there was variation on single causes. Gastroesophageal reflux-related cough was identified in 4.6% of causes. Seasonality, sex, and age were not associated with the spectrum of chronic cough (all P>.05).Conclusion: CVA, UACS, EB, and AC were common causes of chronic cough in China. Geography, seasonality, age, and sex were not associated with the spectrum of chronic cough. CHEST 2013; 143(3):613-620