Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury.
Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury.
复制标题
DOI：
10.1155/2021/1587922
复制
发表时间：
2021
影响因子：
--
通讯作者：
Xing Y
中科院分区：
文献类型：
--
作者：
Li X;Ma N;Xu J;Zhang Y;Yang P;Su X;Xing Y;An N;Yang F;Zhang G;Zhang L;Xing Y
缺血再灌注（I/R）是一种发生于多种器官和疾病的病理过程。再灌注、血流恢复和复氧常常导致再灌注损伤。药物治疗和早期再灌注治疗可以减轻缺血引起的组织损伤和细胞坏死，导致不可逆的I/R损伤。铁凋亡在2012年被明确定义为一种新发现的铁依赖性，过氧化物驱动的，非凋亡形式的调节性细胞死亡。铁凋亡被认为是再灌注损伤的原因。这一发现为疾病的识别和治疗提供了新的途径。铁凋亡是导致I/R损伤和器官衰竭的关键因素。鉴于铁凋亡在I/R损伤中的重要作用，铁凋亡作为广泛的I/R损伤相关疾病的靶向治疗的潜在作用引起了相当大的兴趣。近年来，将铁凋亡应用于各种器官和疾病的I/R损伤已经取得了实质性进展。铁凋亡调节剂的开发有望为I/R损伤的治疗提供新的机会。本文从心肌I/R损伤、脑I/R损伤、缺血性肾损伤等方面，对缺血再灌注及相关疾病中铁凋亡的病理机制和靶向治疗进行综述。
Ischemia-reperfusion (I/R) is a pathological process that occurs in many organs and diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion injury. Drug therapy and early reperfusion therapy can reduce tissue injury and cell necrosis caused by ischemia, leading to irreversible I/R injury. Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. Ferroptosis is a key factor that leads to I/R injury and organ failure. Given the important role of ferroptosis in I/R injury, there is considerable interest in the potential role of ferroptosis as a targeted treatment for a wide range of I/R injury-related diseases. Recently, substantial progress has been made in applying ferroptosis to I/R injury in various organs and diseases. The development of ferroptosis regulators is expected to provide new opportunities for the treatment of I/R injury. Herein, we analytically review the pathological mechanism and targeted treatment of ferroptosis in I/R and related diseases from the perspectives of myocardial I/R injury, cerebral I/R injury, and ischemic renal injury.
登录
查看更多内容
ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M
DOI：
10.1161/circinterventions.111.966226
发表时间：
2012-04-01
影响因子：
5.6
作者：
Chan, William;Taylor, Andrew J.;Duffy, Stephen J.
通讯作者：
Duffy, Stephen J.