Chemokines in the inflammatory bowel diseases
Chemokines in the inflammatory bowel diseases
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DOI：
10.1023/a:1020583306627
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发表时间：
1999-09-01
影响因子：
9.1
通讯作者：
MacDermott, RP
中科院分区：
文献类型：
--
作者：
MacDermott, RP
溃疡性结肠炎和克罗恩病的特征在于慢性肠道炎症。肠道细菌启动肠道炎症过程的激活，其由促炎细胞因子和趋化因子介导。在炎症性肠病中，肠道炎症没有下调，部分原因是抑制过程有缺陷或缺乏。迄今为止的研究表明，IL-8、MCP-1和ENA-78在活动性克罗恩病和溃疡性结肠炎区域的肠粘膜中高度表达。炎症性肠病患者炎症肠道中的中性粒细胞和巨噬细胞合成并分泌大量趋化因子。在上皮细胞、内皮细胞和平滑肌细胞中也观察到趋化因子表达增加。未来能够抑制趋化因子合成和分泌或阻断趋化因子-趋化因子受体相互作用的特异性药物的试验对于溃疡性结肠炎和克罗恩病患者的研究将是重要的。
Ulcerative colitis and Crohn's disease are characterized by chronic intestinal inflammation. Intestinal bacteria initiate the activation of intestinal inflammatory processes, which are mediated by proinflammatory cytokines and chemokines. In inflammatory bowel disease, intestinal inflammation is not downregulated, in part due to defective or absent inhibitory processes. Studies to date have demonstrated that IL-8, MCP-1, and ENA-78 are highly expressed in the intestinal mucosa in areas of active Crohn's disease and ulcerative colitis. Neutrophils and macrophages in the inflamed intestine synthesize and secrete large amounts of chemokines in patients with inflammatory bowel disease. Increased chemokine expression has also been observed in epithelial cells, endothelial cells, and smooth muscle cells. Future trials of specific agents capable of inhibiting chemokine synthesis and secretion or blocking chemokine-chemokine receptor interaction will be important to study in patients with ulcerative colitis and Crohn's disease.