The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
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DOI：
10.1016/j.celrep.2016.01.055
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发表时间：
2016-02-23
期刊：
影响因子：
8.8
通讯作者：
Troemel ER
中科院分区：
文献类型：
--
作者：
Reddy KC;Dunbar TL;Nargund AM;Haynes CM;Troemel ER
病原体通过部署毒素扰乱宿主的核心过程来攻击宿主细胞。最近的研究发现，线虫C。秀丽线虫和其他后生动物表明，监视或“效应触发”途径监测这些核心过程的功能，并在它们受到干扰时产生保护性反应。尽管监视免疫的例子越来越多，但信号成分仍然定义不清。在这里，我们表明，CEBP-2，C。哺乳动物CCAAT增强子结合蛋白γ的秀丽隐杆线虫直系同源物，是监视免疫中的关键参与者。我们表明，CEBP-2与bZIP转录因子ZIP-2一起作用于铜绿假单胞菌外毒素A对翻译阻断的保护性反应，以及对其他过程的干扰。CEBP-2用于限制病原体负荷，促进铜绿假单胞菌感染后的存活，并且还促进外毒素A暴露后的存活。这些发现可能对动物感知病原体攻击并产生保护性反应的机制具有广泛的影响。
Pathogens attack host cells by deploying toxins that perturb core host processes. Recent findings from the nematode C. elegans and other metazoans indicate that surveillance or ‘effector-triggered’ pathways monitor functioning of these core processes and mount protective responses when they are perturbed. Despite a growing number of examples of surveillance immunity, the signaling components remain poorly defined. Here we show that CEBP-2, the C. elegans ortholog of mammalian CCAAT-enhancer binding protein gamma, is a key player in surveillance immunity. We show that CEBP-2 acts together with the bZIP transcription factor ZIP-2 in the protective response to translational block by P. aeruginosa Exotoxin A, as well as to perturbations of other processes. CEBP-2 serves to limit pathogen burden, promote survival upon P. aeruginosa infection, and also promote survival upon Exotoxin A exposure. These findings may have broad implications for the mechanisms by which animals sense pathogenic attack and mount protective responses.