Hydrogel keratophakia in non-human primates.
Hydrogel keratophakia in non-human primates.
复制标题
非人类灵长类动物的水凝胶角膜镜片术。
作者：
P. Binder;J. Deg;E. Zavala;K. Grossman
我们在9只非人类灵长类动物中进行了16次角膜镜片手术，使用各种水凝胶镜片（38%至79%的水）作为供体角膜（晶状体）。使用当前实践的角膜镜片手术将晶状体视为供体人角膜进行处理，包括受体角膜的微型角膜刀切除、冷冻消融前晶状体染色，以及在某些情况下根据修改的计算机程序进行车削，之后将晶状体插入先前解剖的受体板层囊袋中。该技术能够使角膜变陡至44.8屈光度，并且耐受性良好超过三个月。使用水凝胶镜片可能会消除使用人类供体角膜进行无晶状体眼手术矫正的许多负面影响。
We performed sixteen keratophakia procedures in nine non-human primates using various hydrogel lenses (38% to 79% water) as donor corneas (lenticules). The lenses were treated as if they were donor human corneas using currently practiced keratophakia procedures including microkeratome resection of the recipient cornea, staining of the lenses before cryolathing and, in some cases, lathing according to a modified computer program after which the lenses were inserted into a previously dissected recipient lamellar pocket. This technique was able to produce steepening of the cornea up to 44.8 diopters and was well tolerated for over three months. The use of hydrogel lenses could potentially eliminate many of the negative aspects of the use of human donor corneas for the surgical correction of aphakia.