Establishing M1 stage subdivisions by incorporating radiological features and Epstein-Barr virus DNA for metastatic nasopharyngeal carcinoma
Establishing M1 stage subdivisions by incorporating radiological features and Epstein-Barr virus DNA for metastatic nasopharyngeal carcinoma
复制标题
通过结合放射学特征和 Epstein-Barr 病毒 DNA 建立转移性鼻咽癌的 M1 分期细分
DOI：
10.21037/atm.2020.01.13
复制
发表时间：
2020-02-01
影响因子：
--
通讯作者：
Sun, Ying
中科院分区：
文献类型：
--
作者：
Zheng, Wei-Hong;He, Xiao-Jun;Sun, Ying
背景资料：血浆EB病毒脱氧核糖核酸（EBV DNA）的意义-一个被证明是鼻咽癌（NPC）的可靠指标-在转移性NPC（mNPC）的风险分层中尚未阐明。方法：本研究纳入1,007例mNPC患者，其中异时性mNPC（mmNPC）患者817例，随机分为训练组（n=613）和内部验证组（n=204），同步性mNPC（smNPC）患者190例，作为smNPC验证组。主要临床终点为总生存期（OS）。协变量纳入递归分割分析（RPA）生成的风险分层由多变量双侧P
Background: Significance of plasma Epstein-Barr virus deoxyribonucleic acid (EBV DNA)-a proven robust indicator for nasopharyngeal carcinoma (NPC)-is not yet clarified in risk stratification of metastatic NPC (mNPC). We aim to establish effective M1 stage subdivisions in mNPC by integrating radiological features and EBV DNA at diagnosis of metastasis (mEBV DNA).Methods: The study comprised 1,007 mNPC patients, including 817 metachronous mNPC (mmNPC) patients randomized into training (n=613) and internal validation (n=204) cohorts, and 190 synchronous mNPC (smNPC) patients defined as smNPC validation cohort. Primary clinical end-point was overall survival (OS). Covariate inclusion to recursive partitioning analysis (RPA)-generated risk stratification was qualified by a multivariable two-sided P