Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy.
Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy.
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DOI：
10.1093/intimm/dxn001
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发表时间：
2008-03
影响因子：
4.4
通讯作者：
Y. Uemura;Motoharu Suzuki;Tian-yi Liu;Y. Narita;S. Hirata;H. Ohyama;O. Ishihara;S. Matsushita
中科院分区：
文献类型：
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作者：
Y. Uemura;Motoharu Suzuki;Tian-yi Liu;Y. Narita;S. Hirata;H. Ohyama;O. Ishihara;S. Matsushita
产生维持妊娠所必需的T（h）2细胞因子环境的分子和细胞机制仍不完全清楚。我们在此显示人类蜕膜高度富集TCR α β（+）CD161（+）NKT细胞。它们表达由不同TCRV α链和V β链基因片段编码的非恒定抗原受体，因此被称为非恒定NKT（非iNKT）细胞。尽管它们的TCR表达多样，但它们不识别胎儿同种异体抗原，而是特异性地对CD1d转染的细胞系作出反应。与外周血非iNKT细胞相反，蜕膜驻留的非iNKT细胞具有显著的T（h）2偏倚。此外，它们还抑制针对父本抗原的混合白细胞反应。已知T（h）2细胞因子刺激滋养层生长和侵袭。因此，存在于蜕膜组织中的非iNKT细胞可能与表达CD1d的绒毛和绒毛外滋养层细胞具有功能上重要的相互作用，因此可能通过抑制胎儿排斥和促进胎盘生长在成功妊娠中发挥关键作用。这些发现可能反映了一种机制，这是维持妊娠所必需的T（h）2环境的重要组成部分。
The molecular and cellular mechanisms that generate the T(h)2 cytokine environment necessary for the maintenance of pregnancy are still not fully understood. We herein show that the human decidua is highly enriched for TCR alpha beta(+)CD161(+) NKT cells. They express non-invariant antigen receptors encoded by diverse TCRV alpha- and V beta-chain gene segments, thereby referred to as non-invariant NKT (non-iNKT) cells. In spite of their diverse TCR expression, they do not recognize fetal allo-antigens but specifically responded to CD1d-transfected cell lines. In contrast to the peripheral blood non-iNKT cells, the decidua-residing non-iNKT cells had a marked T(h)2 bias. In addition, they suppress the mixed leukocyte reaction directed against the paternal antigens. The T(h)2 cytokines have been known to stimulate trophoblast outgrowth and invasion. Thereby, the non-iNKT cells residing in the decidual tissue may have a functionally important interaction with the villous and extravillous trophoblast cells expressing CD1d and may therefore play a pivotal role in successful pregnancy by inhibiting fetal rejection and enhancing placental growth. These findings may reflect one mechanism that is an essential component for the T(h)2 environment necessary for the maintenance of pregnancy.