Response properties of neurons in the caudate-putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats
Response properties of neurons in the caudate-putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats
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DOI：
10.1016/s0006-8993(98)00971-8
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发表时间：
1998-11-23
期刊：
影响因子：
2.9
通讯作者：
Chudler, EH
中科院分区：
文献类型：
--
作者：
Chudler, EH
为探讨尾壳核（CPu）和苍白球（GP）神经元参与疼痛和伤害性感受的可能机制，本研究观察了麻醉大鼠CPu和GP神经元对非伤害性和伤害性热刺激的反应特性。伤害性CPu和GP神经元能够编码伤害性热刺激，其中79%的热反应神经元也对伤害性机械刺激产生反应。除了平台温度外，热反应神经元在热位移的阶段性上升和下降期间被激活。Cpu和GP神经元编码有害热刺激强度并在刺激的动态阶段做出反应的能力表明，这些神经元可能有助于行为反应，以最大限度地减少身体伤害。(C)1998 Elsevier Science B.V.保留所有权利。
To investigate the possible mechanisms by which neurons in the caudate-putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neurons were capable of encoding noxious thermal stimuli and 79% of these thermally responsive neurons also responded to noxious mechanical stimuli. Thermally responsive neurons were activated during the phasic rise and fall of the thermal shift in addition to the plateau temperature. The ability of Cpu and GP neurons to encode noxious thermal stimulation intensity and respond during the dynamic phase of the stimulus suggests that these neurons may contribute to the behavioral response to minimize bodily harm. (C) 1998 Elsevier Science B.V. All rights reserved.