The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps
The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps
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DOI：
10.4193/rhin17.255
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发表时间：
2019-01-01
期刊：
影响因子：
7.2
通讯作者：
Bachert, Claus
中科院分区：
文献类型：
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作者：
Khan, Asif;Vandeplas, Griet;Bachert, Claus
背景资料：慢性鼻窦炎（CRS）是一种常见的慢性炎症性疾病的鼻子和鼻窦，是根据存在（CRSwNP）或不存在（CRSsNP）的鼻polyps.Methods分类：本文报道的方法和描述性结果的全球过敏和哮喘欧洲网络（GALEN）鼻窦炎队列。我们在GALEN联盟（欧洲FP 6研究计划）中建立了一个大型CRS队列，以确定炎症内型，自然病程及其对健康相关生活质量（HRQoL）的影响。CRS对HRQoL的影响，并发症的发病率，客观的疾病措施，和药物和手术治疗的详细信息collected.Results：这多中心的横断面病例对照研究招募了935名成人（869符合分析：237 CRSsNP; 445 CRSwNP; 187对照[参考组]）。CRS患者的合并症如哮喘、过敏、湿疹、食物过敏、荨麻疹和慢性阻塞性肺疾病的发生率显著更高。鼻用皮质类固醇、抗生素和口服皮质类固醇是最常见的治疗方法。显着更多的CRSwNP患者报告以前sinonasarbure.Conclusions：这项研究提供了详细的信息，有利于研究CRS及其主要表型。然而，本研究的患者分布不一定反映一般人群中的疾病分布。
Background: Chronic rhinosinusitis (CRS) is a common yet under-recognised chronic inflammatory disease of the nose and paranasal sinuses that is classified according to the presence (CRSwNP) or absence (CRSsNP) of nasal polyps.Methods: This paper reports the methodology and descriptive results of the Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort. We established a large CRS cohort within the GALEN consortium (European FP6 research initiative) to identify inflammatory endotypes, the natural disease course, and its impact on health-related quality of life (HRQoL). Detailed information on the impact of CRS on HRQoL, comorbidity incidence, objective disease measures, and medical and surgical treatments were collected.Results: This multicentre cross-sectional case-control study recruited 935 adults (869 eligible for analysis: 237 CRSsNP; 445 CRSwNP; 187 controls [reference group]). Comorbidities such as asthma, allergy, eczema, food allergy, urticaria, and chronic obstructive pulmonary disease were significantly more frequent in CRS patients. Nasal corticosteroids, antibiotics, and oral corticosteroids were the most common treatments. Significantly more CRSwNP patients reported previous sinonasal surgery.Conclusions: This study provides detailed information that facilitates studying CRS and its main phenotypes. However, patient distribution of this study does not necessarily reflect disease distribution in the general population.