Effect of Temporal Resolution on Diagnostic Performance of Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Prostate
Effect of Temporal Resolution on Diagnostic Performance of Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Prostate
复制标题
DOI：
10.1097/rli.0000000000000234
复制
发表时间：
2016-05-01
影响因子：
6.7
通讯作者：
Notohamiprodjo, Mike
中科院分区：
文献类型：
--
作者：
Othman, Ahmed E.;Falkner, Florian;Notohamiprodjo, Mike
目的本研究的目的是评估时间分辨率的影响，半定量和药代动力学参数动态对比增强（DCE）磁共振成像（MRI）和他们的诊断准确性检测潜在的恶性前列腺lesions.Materials和方法60例连续男性患者（年龄64.5 - 7.0岁）与临床怀疑前列腺癌。所有患者均在3 T MRI扫描仪上进行前列腺多参数MRI（T2加权、弥散加权成像和DCE-MRI）。根据前列腺成像报告和数据系统（PI-RADS）评分将患者分为2组（A组：PI-RADS评分3，n = 30; B组：PI-RADS评分>3，n = 30）。在所有患者中，使用CAIPIRINHA-Dixon-TWIST容积内插屏气检查序列（空间分辨率，3 x 1.2 x 1.2 mm;时间分辨率，5秒;总采样持续时间，4：10分钟[250秒]）进行DCE-MRI，并根据体重给予造影剂（钆布醇，Gadovist; Bayer Healthcare，柏林，德国）。从原始数据集回顾性生成了六个具有不同时间分辨率（每个时间点5至30秒）的DCE-MRI系列。计算了不同时间分辨率的半定量参数（即洗脱、洗脱和达峰时间[TTP]）以及药代动力学参数（即K-transs、K-ep和ve）。比较了两个病变组和所有6个DCE-MRI系列的半定量和药代动力学参数。结果时间分辨率对洗入有显著影响（P < 0.001），时间分辨率对洗入有显著影响（P < 0.001），时间分辨率对洗入无显著影响（P> 0.05）。时间分辨率低于10 s/时间点的系列显示，与A组相比，B组的洗入值显著更低，影响更明显。对于30秒系列，两组之间的差异减小至不显著水平（P = 0.052），导致洗入诊断准确性显著降低（曲线下面积，0.609; 95%置信区间，0.451-0.766; P < 0.015）。未检测到对洗脱的显著影响。对于TTP，检测到时间分辨率的显著影响（P < 0.001），与原始5秒系列相比，所有下采样系列的TTP水平显著增加。这些影响并不影响TTP的诊断准确性。结论在前列腺DCE-MRI中，时间分辨率影响半定量参数的诊断性能。为了在DCE-MRI上充分检测恶性前列腺病变，建议时间分辨率至少为10 s/时间点或更高。
Objective The aim of this study was to assess the effect of temporal resolution on semiquantitative and pharmacokinetic parameters from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and their diagnostic accuracy regarding the detection of potentially malignant prostate lesions.Materials and Methods Sixty consecutive male patients (age, 64.5 7.0 years) with clinically suspected prostate cancer were included. All patients underwent multiparametric MRI of the prostate (T2-weighted, diffusion-weighted imaging, and DCE-MRI) on a 3 T MRI scanner. Patients were divided into 2 groups depending on Prostate Imaging Reporting and Data System (PI-RADS) score of the detected lesions (group A: PI-RADS score 3, n = 30; group B: PI-RADS score >3, n = 30). In all patients, DCE-MRI was performed using a CAIPIRINHA-Dixon-TWIST Volume-Interpolated Breath-Hold Examination sequence (spatial resolution, 3 x 1.2 x 1.2 mm; temporal resolution, 5 seconds; total sampling duration, 4:10 minutes [250 seconds]) with body weight-adapted administration of contrast agent (gadobutrol, Gadovist; Bayer Healthcare, Berlin, Germany). Six DCE-MRI series with different temporal resolutions ranging from 5 to 30 seconds per time point were retrospectively generated from the original data sets. Semiquantitative parameters (ie, wash-in, wash-out, and time-to-peak [TTP]) as well as pharmacokinetic parameters (ie, K-trans, K-ep, and ve) were calculated for the different temporal resolutions. Both lesion groups and all 6 DCE-MRI series were compared regarding semiquantitative and pharmacokinetic parameters. Diagnostic accuracy for the detection of potentially malignant lesions was calculated for all 6 series using ROC analysis.Results A significant effect of temporal resolution was found on wash-in (P < 0.001). Series with temporal resolution lower than 10 s/time point showed significantly lower wash-in values with more pronounced effects in group B compared with group A. For 30-second series, the differences between both groups diminished reaching insignificant levels (P = 0.052), resulting in a significant decrease of the diagnostic accuracy of wash-in (area under the curve, 0.609; 95% confidence interval, 0.451-0.766; P < 0.015). No significant effects were detected on wash-out. For TTP, a significant effect of temporal resolution was detected (P < 0.001) with significantly increasing TTP levels for all down-sampled series compared with the original 5-second series. These effects did not impact the diagnostic accuracy of TTP. No significant effects of temporal resolution were detected on pharmacokinetic parameters (P < 0.112).Conclusions In DCE-MRI of the prostate, temporal resolution affects the diagnostic performance of semiquantitative parameters. For a sufficient detection of malignant prostate lesions on DCE-MRI, a temporal resolution of at least 10 s/time point or higher is recommended.