Severe childhood lichen planus pemphigoides after hepatitis A vaccination.
Severe childhood lichen planus pemphigoides after hepatitis A vaccination.
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DOI：
10.1002/ski2.94
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发表时间：
2022-06
影响因子：
--
通讯作者：
Denguezli, M
中科院分区：
文献类型：
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作者：
Lahouel, M;Aounallah, A;Mokni, S;Sriha, B;Belajouza, C;Denguezli, M
类天疱疮样扁平苔癣是一种非常罕见的自身免疫性大疱性疾病，也就是说，儿童例外。我们报告了一例LP类天疱疮伴严重皮肤和粘膜受累的8岁女孩，她因多发性囊泡和大疱性病变伴亮紫色斑块就诊。在接种甲型肝炎病毒疫苗后2个月发生皮疹。病理组织学及免疫荧光检查证实为LP类天疱疮。患者接受口服皮质类固醇治疗后迅速改善。据我们所知，这是成人和儿童接种甲型肝炎疫苗后发生LPP的首次报告。
Lichen planus (LP) pemphigoides (LPP) is a very rare autoimmune bullous disorder, that is, exceptional in children. We report a case of LP pemphigoides with severe cutaneous and mucosal involvement in an 8‐year‐old girl who consulted for multiple vesicular and bullous lesions associated with shiny erythematous‐purple plaques. The eruption occurred 2 months after vaccination against hepatitis A virus. The diagnosis of LP pemphigoides was confirmed by histopathology and immunofluorescence examination. The patient received oral corticosteroid therapy with rapid improvement. To our knowledge, this is the first report of LPP following hepatitis A vaccination, among adults and children.