Synthesis of Hindered Anilines: Three-Component Coupling of Arylboronic Acids, tert-Butyl Nitrite, and Alkyl Bromides
Synthesis of Hindered Anilines: Three-Component Coupling of Arylboronic Acids, tert-Butyl Nitrite, and Alkyl Bromides
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DOI：
10.1021/acs.orglett.6b02523
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发表时间：
2016-10-07
期刊：
影响因子：
5.2
通讯作者：
de Alaniz, Javier Read
中科院分区：
文献类型：
--
作者：
Fisher, David J.;Shaum, James B.;de Alaniz, Javier Read
The synthesis of sterically hindered amines has been a significant challenge in organic chemistry. Herein, we report a modular, three-component coupling that constructs two carbon-nitrogen bonds including a sterically hindered C-sp(3)-N bond, using commercially available materials. This process uses an earth-abundant copper catalyst and mild reaction conditions, allowing access to a variety of complex aromatic amines.
