Relationship between fecal calprotectin level and disease activity in patients with hidradenitis suppurativa
Relationship between fecal calprotectin level and disease activity in patients with hidradenitis suppurativa
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DOI：
10.1111/dth.13232
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发表时间：
2020-02-05
影响因子：
3.6
通讯作者：
Askin, Ozge
中科院分区：
文献类型：
--
作者：
Eser, Emel;Engin, Burhan;Askin, Ozge
背景化脓性汗管炎是一种慢性、炎症性、复发性疾病，伴有反复的脓肿和窦道形成，导致瘢痕形成。钙保护素具有免疫调节、抗微生物和抗增殖特性，是一种钙结合蛋白，主要存在于中性粒细胞胞浆中。目的探讨化脓性汗腺炎患者疾病活动性与粪便钙保护素水平的关系。方法选择2017年12月6日至2018年4月6日在皮肤科就诊的化脓性汗腺炎患者50例(病例组)，健康志愿者36例(对照组)。结果活动期化脓性汗腺炎患者粪便钙保护素水平明显高于缓解期患者，差异有统计学意义(p<；.001)。化脓性汗腺炎患者的疾病分期和粪便钙保护素水平之间没有统计学意义的相关性(p=0.14)。年龄、性别、吸烟和饮酒、抗肿瘤坏死因子-α治疗和粪便钙保护素水平没有显著相关性。在本研究中，化脓性汗腺炎活动期患者粪便钙保护素水平明显高于住院缓解期患者(P<；.001)。结论粪便钙保护素可作为化脓性汗腺炎病情活动性的指标。
Background Hidradenitis suppurativa is a chronic, inflammatory, recurrent disease with recurrent abscesses, and sinus tract formation leading to scarring. Calprotectin has immunomodulatory, antimicrobial, and antiproliferative properties and is a calcium-binding protein primarily found in the neutrophil cytoplasm. In recent years, a significant relationship between the activity of various diseases and the level of calprotectin has led to the conclusion that there may be a similar relationship in hidradenitis suppurativa.Objective To determine the relationship between disease activity and fecal calprotectin levels in patients with hidradenitis suppurativa.Methods Fifty patients with hidradenitis suppurativa (case group) who present to the Dermatology and Venerology Department between December 6, 2017, and April 6, 2018, and 36 healthy volunteers (control group) were enrolled in our study. Fecal calprotectin levels we requantitatively calculated using enzyme-linked immunosorbent assay.Results In patients with active hidradenitis suppurativa, the level of stool calprotectin was higher than that of patientsin remission, and this difference was statistically significant (p < .001). There was no statistically significant correlation between disease stage and fecal calprotectin levels in patients with hidradenitis suppurativa (p = .14). Age, sex, smoking and alcohol use, anti-TNF-alpha treatment, and fecal calprotectin levels were not significantly correlated. In our study, fecal calprotectin levels in patients with active hidradenitis suppurativa were higher than inpatients in remission (p < .001).Conclusion Fecal calprotectin can beused as a marker of disease activity in hidradenitis suppurativa.