Cortisol feedback during the HPA quiescent period in patients with major depression.
Cortisol feedback during the HPA quiescent period in patients with major depression.
复制标题
重度抑郁症患者 HPA 静止期的皮质醇反馈。
DOI：
10.1176/appi.ajp.158.12.2083
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Schatzberg,AF
中科院分区：
文献类型：
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作者：
Posener,JA;DeBattista,C;Williams,GH;Schatzberg,AF
作者测试了这一假设，即重度抑郁症患者在皮质醇对下丘脑-垂体-肾上腺（HPA）轴施加负反馈的机制中存在缺陷，在HPA轴静止期，29名重度抑郁症患者和25名健康对照受试者被随机分配给15 mg皮质醇或安慰剂，从7：00开始输注2小时以上。00 p.m.皮质醇和促肾上腺皮质激素水平测定在基线和每30分钟从下午7：30到11：00 p.m. APARTISDIFFERENCE患者和比较对象之间的差异，在促肾上腺皮质激素反应的皮质醇输液，相对于促肾上腺皮质激素反应安慰剂，没有发现。CONCLUSIONSThe结果提供了一些证据表明，抑郁症患者没有异常的皮质醇反馈在HPA轴静止期。
OBJECTIVEThe authors tested the hypothesis that patients with major depression have a defect in the mechanism by which cortisol exerts negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis during the HPA axis quiescent period.METHODTwenty-nine patients with major depression and 25 healthy comparison subjects were randomly assigned to administration of 15 mg cortisol or placebo infused over 2 hours beginning at 7:00 p.m. Cortisol and ACTH levels were measured at baseline and every 30 minutes from 7:30 p.m. to 11:00 p.m.RESULTSDifferences between the patients and the comparison subjects in the ACTH response to the cortisol infusion, relative to the ACTH response to placebo, were not found.CONCLUSIONSThe results provide some evidence that patients with major depression do not have an abnormality of cortisol feedback during the HPA axis quiescent period.