Structural elements involved in activation of the γ-aminobutyric acid type A (GABAA)receptor
Structural elements involved in activation of the γ-aminobutyric acid type A (GABAA)receptor
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DOI：
10.1042/bst0320540
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发表时间：
2004-06-01
影响因子：
3.9
通讯作者：
Harrison, NL
中科院分区：
文献类型：
--
作者：
Kash, TL;Trudell, JR;Harrison, NL
配体门控离子通道充当快速信号转换器，将化学信号（以神经递质的形式）转换为突触后神经元中的电信号。这是通过在其特异性结合位点识别神经递质来实现的，然后触发离子通道的打开（“门控”）。为了迅速实现这一目标，
Ligand-gated ion channels function as rapid signal transducers, converting chemical signals (in the form of neurotransmitters) into electrical signals in the postsynaptic neuron. This is achieved by the recognition of neurotransmitter at its specific-binding sites, which then triggers the opening of an ion channel ('gating'). For this to occur rapidly (