Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome.
Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome.
复制标题
患有骨肉瘤和 22q11.2 缺失综合征的患者出现低钙血症。
DOI：
10.1097/mph.0b013e318168f072
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kim,SuYoung
中科院分区：
文献类型：
--
作者：
Mussai,FrancisJ;Cunningham,LeaC;Rezvani,Geoffrey;Stratakis,ConstantineA;Reynolds,JamesC;Nesterova,Galina;Henshaw,RobertM;Levine,JasonE;Helman,LeeJ;Arthur,DianeC;Kim,SuYoung
Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11. 2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11. 2 deletion syndrome.
