Neonatal factors influence adult stroke outcome
Neonatal factors influence adult stroke outcome
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DOI：
10.1016/j.psyneuen.2006.01.002
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发表时间：
2006-06-01
影响因子：
3.7
通讯作者：
DeVries, A. Courtney
中科院分区：
文献类型：
--
作者：
Craft, Tara K. S.;Zhang, Ning;DeVries, A. Courtney
新生儿环境对应激反应性和下丘脑-垂体-肾上腺（HPA）轴的调节具有重要的终身影响。在啮齿类动物中，短暂的母婴分离已被证明可以提高HPA轴的效率，降低应激反应性，并减少与年龄相关的认知功能下降。在这里，我们提供的证据表明，有潜在的成本与改善HPA轴的调节，包括增加敏感性脑炎症和糖皮质激素介导的神经元死亡后中风。具体而言，短暂的母婴分离降低了成年小鼠对实验性卒中的初始皮质类固醇反应，但与缺血对照组相比，增加了卒中后促炎细胞因子表达、水肿和梗死体积。短暂的母亲分离也会影响中风后的功能恢复和长期生存。此外，肾上腺切除术逆转了短暂的母体分离对卒中结局的影响时，皮质酮被替换为基线，但不是缺血，浓度;因此，分离的小鼠更敏感的皮质酮升高在缺血期间的有害影响。总之，这些数据提供了第一个直接证据，新生儿环境可以大大影响成人脑血管健康。(c)2006爱思唯尔有限公司保留所有权利。
Neonatal environment can have important, life-long influences on stress-reactivity and hypothalamic-pituitary-ad renal (HPA) axis regulation. In rodents, brief mother-infant separations have been shown to improve efficiency of the HPA axis, decrease stress-reactivity, and decrease age-related declines in cognitive function. Here, we provide evidence that there are potential costs associated with improved HPA axis regulation, including increased sensitivity to cerebral inflammation and glucocorticoid-mediated neuronal death following stroke. Specifically, brief mother-infant separation decreases the initial corticosteroid response to experimental stroke in adult mice, but increases post-stroke proinflammatory cytokine expression, edema, and infarct volume compared to ischemic controls. Brief maternal separation also compromises functional recovery and longterm survival following stroke. In addition, adrenalectomy reverses the effects of brief maternal separation on stroke outcome when corticosterone is replaced at baseline, but not ischemic, concentrations; thus, neonatally separated mice are more sensitized as adults to the detrimental effects of elevated corticosterone during ischemia. Taken together, these data provide the first direct evidence that neonatal environment can substantially influence adult cerebrovascular health. (c) 2006 Elsevier Ltd. All rights reserved.