Neural tube defects and maternal hyperthermia in early pregnancy: epidemiology in a human embryo population.
Neural tube defects and maternal hyperthermia in early pregnancy: epidemiology in a human embryo population.
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妊娠早期神经管缺陷和母亲高热：人类胚胎群体的流行病学。
DOI：
10.1002/ajmg.1320120306
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Shiota,K
中科院分区：
文献类型：
--
作者：
Shiota,K
利用来自日本的人类胚胎数据，回顾性研究了神经管缺陷与妊娠早期母体发热性疾病之间的因果关系。发热性疾病的频率与正常对照组、前脑无裂畸形和多指畸形胚胎的相应数据进行了比较。在神经管缺陷组中，母亲体温过高的患病率明显高于正常对照组和前脑无裂畸形母亲。这种关联是恒定的，特别是对于露脑畸形，这是无脑畸形的胚胎前兆。与脊髓劈裂（无露脑）的相关性不显著。在10例已知发热时间的病例中，有8例发生在临床确定的人类胚胎神经管闭合的关键时期。这些结果支持了孕早期母体体温过高可导致男性神经管畸形，尤其是无脑儿的假设。
A causal relationship between neural tube defects and maternal febrile illness in early pregnancy was investigated retrospectively using human embryo data from Japan. The frequency of febrile illness was compared with corresponding data from normal controls, and holoprosencephalic and polydactylous embryos. Within the group of neural tube defects, the prevalence of maternal hyperthermia was significantly higher than in normal control and holoprosencephaly mothers. The association was constant and highly significant specifically for exencephaly, which is an embryonic forerunner of anencephaly. The correlation with myeloschisis (without exencephaly) was not significant. In eight out of the ten cases in which the timing of the fever was known, it occurred during the clinically determined critical period of neural tube closure in human embryos. These results support the hypothesis that maternal hyperthermia in early pregnancy can cause neural tube defects in man, especially anencephaly.