Anatomy and physiology of saccadic long-lead burst neurons recorded in the alert squirrel monkey. II. Pontine neurons.
Anatomy and physiology of saccadic long-lead burst neurons recorded in the alert squirrel monkey. II. Pontine neurons.
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警觉松鼠猴中记录的扫视长导爆神经元的解剖学和生理学。
DOI：
10.1152/jn.1996.76.1.353
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Highstein,SM
中科院分区：
文献类型：
--
作者：
Scudder,CA;Moschovakis,AK;Karabelas,AB;Highstein,SM
1.采用轴突内记录和辣根过氧化物酶注射的方法，研究了警觉松鼠脑桥网状结构内有胞体的突触长导联爆发神经元(LLBN)的放电模式和轴突投射。2.小脑传入神经元是染色神经元最多的部位。它们起源于脑桥背内侧被盖网状核(NRTP)，包括其背侧细胞群(N=5)、展前束内核(N=5)和中缝脑桥(N=1)。在NRTP作用下，所有神经元的轴突均进入桥臂，但未与脑干发生突触。三个轴突将侧支发送到小叶，但这些和其他小脑传入的其他更远的目标无法确定。这些神经元的运动场介于矢状型和方向型之间。3.4个神经元的胞体位于脑桥口侧网状核，终末位于脑干网状结构。每个神经元都不同，但都终止于包含兴奋性爆发神经元的区域，大部分终止于包含抑制性爆发神经元的区域。其他靶点包括脑桥和尾侧网状核、NRTP、中缝间位和脊髓。放电模式包括矢状型和方向型。4.两个网状脊髓神经元在展肌核的吻侧或腹侧有大的多极胞体。这些神经元还投射到延髓网状结构、舌下前置尾侧核、背侧和腹侧旁正中网状核。5.广泛讨论了这些LLBN的连接以及相关文件中报告的LLBN的功能含义。上丘的传出以含有中导联眼跳爆发神经元的区域为靶点，这一事实证实了上丘在眼跳发生中的作用。然而，许多其他神经元投射到这些区域的发现，以及上丘传出更多投射到含有网状脊髓神经元的区域的发现，证明了上丘在眼跳产生中的作用减弱，但在头部运动控制中的作用增强。
1. The discharge patterns and axonal projections of saccadic long-lead burst neurons (LLBNs) with somata in the pontine reticular formation were studied in alert squirrel monkeys with the use of the method of intraaxonal recording and horseradish peroxidase injection. 2. The largest population of stained neurons were afferents to the cerebellum. They originated in the dorsomedial nucleus reticularis tegmenti pontis (NRTP) including its dorsal cell group (N = 5), the preabducens intrafascicular nucleus (N = 5), and the raphe pontis (N = 1). Axons of all neurons coursed under NRTP and entered brachium pontis without having synapsed in the brain stem. Three axons sent collaterals to the floccular lobe, but other more distant targets of these and the other cerebellar afferents could not be determined. Movement fields of these neurons were intermediate between vectorial and directional types. 3. Four neurons had their somata in nucleus reticularis pontis oralis and terminations in the brain stem reticular formation. Each neuron was different, but all terminated in the region containing excitatory burst neurons, and most terminated in the region containing inhibitory burst neurons. Other targets include nucleus reticularis pontis oralis and caudalis, NRTP, raphe interpositus, and the spinal cord. Discharge patterns included both vectorial and directional types. 4. Two reticulospinal neurons had large multipolar somata either just rostral or ventral to the abducens nucleus. These neurons also projected to the medullary reticular formation, caudal nucleus prepositus hypoglossi, and dorsal and ventral paramedian reticular nucleus. 5. The functional implications of the connections of these LLBNs and those reported in the companion paper are extensively discussed. The fact that the efferents of the superior colliculus target the regions containing medium-lead saccadic burst neurons confirms the role of the colliculus in saccade generation. However, the finding that many other neurons project to these regions and the finding that superior colliculus efferents project more heavily to areas containing reticulospinal neurons argue for a diminished role of the superior colliculus in saccade generation but an augmented role in head movement control.