Neural correlates of non-specific skin conductance responses during resting state fMRI.
Neural correlates of non-specific skin conductance responses during resting state fMRI.
复制标题
静息状态功能磁共振成像期间非特异性皮肤电导反应的神经相关性。
DOI：
10.1016/j.neuroimage.2020.116721
复制
发表时间：
2020
期刊：
影响因子：
5.7
通讯作者：
Stevens,MichaelC
中科院分区：
文献类型：
--
作者：
Gertler,Joshua;Novotny,Stephanie;Poppe,Andrew;Chung,YuSun;Gross,JamesJ;Pearlson,Godfrey;Stevens,MichaelC
皮肤电导反应（SCR）在没有外部刺激的情况下可靠地发生。然而，这些非特异性SCR的神经相关性比与刺激引起的SCR相关的脑活动探索得更少。本研究模拟自发皮肤电导反应观察期间，在非结构化静息状态功能磁共振成像扫描在58名青少年。使用有限脉冲响应（FIR）fMRI模型来检测时间锁定到非特异性SCR的任何类型的血流动力学响应形状;然后仔细表征这些响应的形状。信号变化的最强有力的证据被发现在感觉运动皮层的几个子区域。也有证据表明，在顶叶，扣带皮层，额岛盖，视觉和听觉初级处理区的侧表面内的离散区域的参与。通过FIR建模测量的血流动力学曲线明显类似于事件相关反应。然而，这是一个复杂的反应，最好的解释是两个快速连续的，但相反的神经冲动在所有的大脑区域-一个简短的积极反应，开始前几秒钟的SCR与一个更长的负神经冲动开始后不久的SCR onset.Post探索性分析这两个血流动力学反应阶段不同的情绪相关的个体差异。总之，这项研究表明，非特异性SCR的神经相关性是一个广泛的，大脑区域的皮质网络，参与了一个复杂的，看似双相的方式。在复制研究中，试图将大脑活动与可能的稳态机制直接联系起来或寻找替代机制的证据时，应考虑这种双峰反应特征。
Skin conductance responses (SCRs) reliably occur in the absence of external stimulation. However, the neural correlates of these non-specific SCRs have been less explored than brain activity associated with stimulus-elicited SCRs. This study modeled spontaneous skin conductance responses observed during an unstructured resting state fMRI scan in 58 adolescents. A Finite Impulse Response (FIR) fMRI model was used to detect any type of hemodynamic response shape time-locked to non-specific SCRs; the shape of these responses was then carefully characterized. The strongest evidence for signal change was found in several sub-regions of sensorimotor cortex. There also was evidence for engagement of discrete areas within the lateral surfaces of the parietal lobe, cingulate cortex, fronto-insular operculum, and both visual and auditory primary processing areas. The hemodynamic profile measured by FIR modeling clearly resembled an event-related response. However, it was a complex response, best explained by two quickly successive, but opposing neuronal impulses across all brain regions – a brief positive response that begins several seconds prior to the SCR with a much longer negative neuronal impulse beginning shortly after the SCR onset.Post hocexploratory analyses linked these two hemodynamic response phases to different emotion-related individual differences. In conclusion, this study shows the neural correlates of non-specific SCRs are a widespread, cortical network of brain regions engaged in a complex, seemingly biphasic fashion. This bimodal response profile should be considered in replication studies that attempt to directly link brain activity to possible homeostatic mechanisms or seek evidence for alternative mechanisms.