Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters.
Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters.
复制标题
基底外侧杏仁核和眶额皮质，但不是背侧海马，对于控制场合设定者寻求奖励是必需的。
DOI：
10.1007/s00213-022-06227-0
复制
发表时间：
2023
影响因子：
3.4
通讯作者：
Janak,PatriciaH
中科院分区：
文献类型：
--
作者：
Fraser,KurtM;Janak,PatriciaH
在这个世界上，寻求奖励是由具有模糊预测和激励价值的线索驱动的。为了产生自适应的，灵活的奖励寻求，有必要利用场合设置者，环境中的其他不同特征，以解决巴甫洛夫奖励配对线索的歧义。尽管如此，很少有研究调查了场合设置的神经生物学基础，因此很少有人知道哪些大脑区域对场合设置至关重要。为了解决这个问题，我们利用了最近开发的任务，是服从神经生物学的调查条件刺激是唯一的预测奖励交付，如果之前的时间由一个单独的线索，一个场合设置的非重叠的介绍。这项任务要求雄性大鼠在一段时间内维持和连接线索触发的期望，以产生适应性的奖励寻求。我们询问了基底外侧杏仁核和眶额皮层的贡献场合设置，因为这些地区被认为是至关重要的计算和开发的状态值，分别。可逆失活的任何结构之前的奖励设置任务导致大鼠无法使用的场合设置指导奖励寻求。与此相反，背侧海马，一个区域的基本上下文特异性反应的失活没有影响，也没有失活的基底外侧杏仁核或眶额皮质在一个标准的巴甫洛夫条件反射制剂影响条件反射。我们的结论是，眶额皮层和基底外侧杏仁核电路内的神经活动是必要的更新和解决环境中的歧义，以促进线索驱动的奖励寻求。
Reward-seeking in the world is driven by cues that can have ambiguous predictive and motivational value. To produce adaptive, flexible reward-seeking, it is necessary to exploit occasion setters, other distinct features in the environment, to resolve the ambiguity of Pavlovian reward-paired cues. Despite this, very little research has investigated the neurobiological underpinnings of occasion setting, and as a result little is known about which brain regions are critical for occasion setting. To address this, we exploited a recently developed task that was amenable to neurobiological inquiry where a conditioned stimulus is only predictive of reward delivery if preceded in time by the non-overlapping presentation of a separate cue—an occasion setter. This task required male rats to maintain and link cue-triggered expectations across time to produce adaptive reward-seeking. We interrogated the contributions of the basolateral amygdala and orbitofrontal cortex to occasion setting as these regions are thought to be critical for the computation and exploitation of state value, respectively. Reversible inactivation of either structure prior to the occasion-setting task resulted in a profound inability of rats to use the occasion setter to guide reward-seeking. In contrast, inactivation of the dorsal hippocampus, a region fundamental for context-specific responding was without effect nor did inactivation of the basolateral amygdala or orbitofrontal cortex in a standard Pavlovian conditioning preparation affect conditioned responding. We conclude that neural activity within the orbitofrontal cortex and basolateral amygdala circuit is necessary to update and resolve ambiguity in the environment to promote cue-driven reward-seeking.