ATLV IN JAPANESE PATIENT WITH AIDS
ATLV IN JAPANESE PATIENT WITH AIDS
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日本艾滋病患者的 ATLV
DOI：
10.1016/s0140-6736(83)90252-0
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Y. Ohtsuki
中科院分区：
文献类型：
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作者：
I. Miyoshi;Makoto Kobayashi;S. Yoshimoto;M. Fujishita;H. Taguchi;I. Kubonishi;Y. Ohtsuki
考虑到获得性免疫缺陷综合征(AIDS)和人类T细胞白血病病毒(HTLV)之间的联系，作者重新检查了一名同时患有卡氏肺孢子虫肺炎和溃烂的患者[见Abst。HYG，1983，58，Abst.3148]。当时，这名患者是一名36岁的日本女性，除了PPD皮肤测试呈阴性外，其他免疫检测结果正常。一年后复查，发现其辅助/抑制T细胞比例倒置，血细胞计数3.2×10~9/L，淋巴细胞占42%。用电子显微镜在培养的淋巴细胞中发现C型逆转录病毒颗粒(ATLV)，病程中和复查时采集的血清标本均为ATLV相关抗原阳性。这份报告描述了首例具有艾滋病临床特征的日本患者。作者不知道ATLV感染是她免疫缺陷的原因还是结果。
In view of the suggested link between the acquired immune deficiency syndrome (AIDS) and human T-cell leukaemia virus (HTLV) the authors re-examined a patient who had had concurrentPneumocystis cariniipneumonia and scabies [seeAbst. Hyg.,1983,58,abst. 3148]. At that time the patient, a 36-year-old Japanese woman, had normal immunological test results except for negative PPD skin tests. A year later, on re-examination, she was found to have a reversed helper/suppressor T-cell ratio and a blood-count of 3.2 × 109/l with 42% lymphocytes. Type C retrovirus particles (ATLV) were found in cultured lymphocytes by electron microscopy and serum samples taken during the course of her illness and on re-examination all were positive for ATLV-associated antigens. This report describes the first Japanese patient with clinical features of AIDS. The authors do not know whether the ATLV infection was the cause or the result of her immunodeficiency.D.W. FitzSimons