ROLE OF IRON IN MECHANISM OF EXPERIMENTAL CALCIFICATION
ROLE OF IRON IN MECHANISM OF EXPERIMENTAL CALCIFICATION
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DOI：
10.1177/11.6.799
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发表时间：
1963-01-01
影响因子：
3.2
通讯作者：
TUCHWEBER, B
中科院分区：
文献类型：
--
作者：
GABBIANI, G;TUCHWEBER, B
用1mg二氢速甾醇致敏后，用各种铁化合物（FeCl_2、FeCl_3、右旋糖酐铁、糊精铁、氧化亚铁）静脉注射诱发大鼠不同器官的钙化，用组织化学方法进行了研究。Fe（普鲁士蓝反应）在钙化前的靶器官中是明显的，但显然，在所描述的实验条件下，它只能吸引细胞外的Ca（von Kossa）。Fe在诱导选择性钙化过程中起着重要作用，一旦被网状内皮系统细胞和结缔组织巨噬细胞吞噬，Fe似乎就失去了诱导钙盐沉淀的能力。
Calcification of different organs in the rat, induced by intravenous challenge with various Fe compounds (FeCl2, FeCl3, ferric dextran, ferric dextrin, ferric oxisaccharated) after sensitization with 1 mg of dihydrotachysterol, was studied histochemically. Fe (Prussian blue reaction) is demonstrable in the target organs before calcification but apparently, in the described experimental conditions, it can attract Ca (von Kossa) only when it is extracellular. Fe plays an important role in the process of induced selective calcification, and it seems to lose its capacity to induce precipitation of Ca salts once it is phagocytized by the cells of the reticuloendothelial system and by the macrophages of the connective tissue.