PERSISTENT CHANGES IN BEHAVIOR AND BRAIN-SEROTONIN DURING AGING IN RATS SUBJECTED TO INFANT NASAL VIRUS-INFECTION
PERSISTENT CHANGES IN BEHAVIOR AND BRAIN-SEROTONIN DURING AGING IN RATS SUBJECTED TO INFANT NASAL VIRUS-INFECTION
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DOI：
10.1016/0197-4580(92)90013-n
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发表时间：
1992-01-01
影响因子：
4.2
通讯作者：
KRISTENSSON, K
中科院分区：
文献类型：
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作者：
MOHAMMED, AKH;MAEHLEN, J;KRISTENSSON, K
用温度敏感型水泡性口炎病毒G41突变株对哺乳大鼠进行鼻内感染。大鼠活了下来，但在莫里斯迷宫中表现出终身学习缺陷，在开阔场地测试中表现出探索行为受损。在18个月大时进行检查时，他们的脑干中缝核和中缝背核的神经元严重丧失，大脑新皮层和海马体中血清素及其代谢物5-羟基吲哚乙酸的水平降低。去甲肾上腺素、多巴胺、同型香草酸、3,4-二羟基苯乙酸、胆碱乙酰转移酶和谷氨酸脱羧酶的水平基本未受影响。脑5 -羟色胺代谢的永久性紊乱未引起大脑皮层的任何组织学改变。因此，没有神经原纤维缠结或淀粉样斑块，这是报道的化学诱导的大鼠脑胆碱能系统损伤的晚期效应。由此得出的结论是，大脑的血清素能系统特别容易受到病毒沿嗅觉通路发作的攻击，而且这种发作引起的神经化学和行为改变会在动物生命的大部分时间内持续存在。
Suckling rats were infected intranasally with the temperature-sensitive mutant G41 strain of vesicular stomatitis virus. The rats survived but demonstrated lifelong learning deficits in the Morris maze and impaired exploratory behaviour in the open field test. When examined at 18 months of age they had a severe loss of neurons in the medial and dorsal raphe nuclei in the brain stem and reduced levels of serotonin and its metabolite 5-hydroxyindole acetic acid in the cerebral neocortex and hippocampus. The levels of noradrenaline, dopamine, homovanillic acid, 3,4-dihydroxyphenylacetic acid, choline acetyltransferase and glutamate decarboxylase were largely unaffected. The permanent disturbance in brain serotonin metabolism did not cause any histological changes in the cerebral cortex. Thus there were no neurofibrillary tangles or amyloid plaques as has been reported as a late effect of chemically induced lesion to the cholinergic system in the rat brain. It is concluded that the brain serotonergic system is especially vulnerable to an episode of virus attack along olfactory pathways and that the neurochemical and behavioural alterations caused by such an episode persist during a major part of the animal's life span.