Quantifying influenza vaccine efficacy and antigenic distance
Quantifying influenza vaccine efficacy and antigenic distance
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DOI：
10.1016/j.vaccine.2006.01.010
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发表时间：
2006-05-01
期刊：
影响因子：
5.5
通讯作者：
Deem, Michael W.
中科院分区：
文献类型：
--
作者：
Gupta, Vishal;Earl, David J.;Deem, Michael W.
我们介绍了一种新的测量甲型流感疫苗和流行毒株之间抗原距离的方法。这一措施与1971年至2004年间年度疫苗中H3N2甲型流感成分的有效性密切相关，接种疫苗后流感免疫反应理论的结果也与此密切相关。与目前先进的系统发育序列分析或雪貂抗血清抑制试验相比，这种新的抗原距离测量方法与疫苗效力的相关性更大。我们建议将这种新的抗原距离测量方法用于年度流感疫苗的设计和疫苗功效监测的解释。(c) 2006 Elsevier Ltd.版权所有。
We introduce a new measure of antigenic distance between influenza A vaccine and circulating strains. The measure correlates well with efficacies of the H3N2 influenza A component of the annual vaccine between 1971 and 2004, as do results of a theory of the immune response to influenza following vaccination. This new measure of antigenic distance is correlated with vaccine efficacy to a greater degree than are current state of the art phylogenetic sequence analyses or ferret antisera inhibition assays. We suggest that this new measure of antigenic distance be used in the design of the annual influenza vaccine and in the interpretation of vaccine efficacy monitoring. (c) 2006 Elsevier Ltd. All rights reserved.