Haemodynamic effects of phentolamine in chronic obstructive pulmonary disease.
Haemodynamic effects of phentolamine in chronic obstructive pulmonary disease.
复制标题
酚妥拉明对慢性阻塞性肺疾病的血流动力学影响。
作者：
L. Gould;M. Zahir;A. DeMartino;R. Gomprecht
对10例慢性阻塞性肺疾病（COPD）无肺心病患者进行了左、右心导管检查。呼吸和血液动力学观察期间的控制期间和酚妥拉明的输液。酚妥拉明使平均肺动脉压从18.8mmHg降至13.1mmHg，右室舒张末压从18mmHg降至0.1mmHg，左室舒张末压从8.2mmHg降至1.9mmHg。平均肱动脉压、心脏指数和肺血管阻力基本不变。结论：患者对酚妥拉明的血流动力学反应不能用单一机制来解释。必须考虑药物的多种作用，包括主动肺血管舒张，
Ten patients with chronic obstructive pulmonary disease without complicating cor pulmonale were studied by right and left heart catheterization. Respiratory and haemodynamic observations were made during a control period and during the infusion of phentolamine. Phentolamine produced a significant reduction in mean pulmonary artery pressure from I8 8 mmHg to I3 I mmHg, right ventricular end-diastolic pressure from i 8 mmHg to o*i mmHg, and left ventricular end-diastolic pressure from 8 2 mmHg to I -9 mmHg. The mean brachial artery pressure, cardiac index, and pulmonary vascular resistance were essentially unchanged. It is concluded that the haenodynamic response of the patients to phentolamine cannot be explained by a single mechanism. Multiple actions of the drug must be considered, including active pulmonary vasodilatation, and