THE BINDING OF HAEMOGLOBIN BY PLASMA PROTEINS (HAPTOGLOBINS) - ITS BEARING ON THE RENAL THRESHOLD FOR HAEMOGLOBIN AND THE AETIOLOGY OF HAEMOGLOBINURIA
THE BINDING OF HAEMOGLOBIN BY PLASMA PROTEINS (HAPTOGLOBINS) - ITS BEARING ON THE RENAL THRESHOLD FOR HAEMOGLOBIN AND THE AETIOLOGY OF HAEMOGLOBINURIA
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DOI：
10.1136/bmj.2.5054.1137
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发表时间：
1957-01-01
影响因子：
--
通讯作者：
REES, W
中科院分区：
文献类型：
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作者：
ALLISON, AC;REES, W
本文报告了24例结核菌素反应阴性的各种疾病患者。用中、低剂量可的松或泼尼松龙治疗时，20例在相同或更高稀释度下结核菌素反应转为阳性。患者大多是老年人，或表现出明显的肾上腺皮质抑制的迹象。建议类固醇治疗，虽然能够抑制结核菌素阳性反应时，在高剂量，在较低剂量，实际上可能恢复反应已被抑制的年龄，感染，或肾上腺缺乏。这些研究结果的意义和他们可能的应用，以治疗严重的感染，特别是在老年人，进行了讨论。我感谢艾尔斯伯里医院的医生允许调查他们的病人，特别是博士威尔弗雷德斯托克斯和博士M。Saxty好很多宝贵的建议和批评。我也要感谢L博士。纳恩进行生化检查，护理人员协助进行结核菌素反应。
The cases are presented of 24 patients with various diseases who had negative tuberculin reactions. Whilst treated with cortisone or prednisolone in moderate or low dosage the tuberculin reaction became positive at the same or higher dilutions in 20 of the cases. The-patients were mostly elderly, or showed frank signs of suprarenal cortical suppression. The suggestion is made that steroid treatment, although able to suppress a positive tuberculin reaction when given in high dosage, may, given in lower dosage, actually restore a reaction which has been suppressed by age, infection, or suprarenal deficiency. The implications of these findings and their possible application to the treatment of severe infections, especially in the elderly, are discussed.I thank the physicians of the Aylesbury Hospitals for permis-sion to investigate their patients, and in particular Dr. Wilfred Stokes and Dr. M. Saxty Good for much valuable advice and criticism. I also thank Dr. L. Nunn for the biochemical investi-gations and the nursing staff for assistance with the tuberculin reactions.