A Critical Review on Chagas Disease Chemotherapy
A Critical Review on Chagas Disease Chemotherapy
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DOI：
10.1590/s0074-02762002000100001
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发表时间：
2002-01-01
期刊：
影响因子：
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通讯作者：
Castro, Solange L de
中科院分区：
文献类型：
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作者：
Coura, José Rodrigues;Castro, Solange L de
在这篇“评论”中，我们从1912年迈耶和罗查·利马的工作开始，对治疗恰加斯病的药物进行了历史性的介绍，直到呋喃西林的实验性使用。70年代初，硝呋莫司和苯硝唑被引入临床治疗，但结果差异很大，对于它们在慢性病例中的使用仍存在争议。在引入这些硝基杂环后，在查热症患者中只检测到了少数化合物。南锥体国家在病媒控制方面取得的巨大进展，以及在慢性患者中发现寄生虫，表明在这一阶段讨论病原学治疗的紧迫性，加强了寻找更有效和更低毒性药物的必要性。我们还回顾了寄生虫中的潜在靶点，并介绍了1992/1993年后研究的新的合成化合物和天然化合物的概况，我们打算通过这些综述向读者介绍查加斯病化学治疗领域的实验研究，补充Brener(1979)和De Castro(1993)之前的论文。
In this "Critical Review" we made a historical introduction of drugs assayed against Chagas disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental use of nitrofurazone. In the beginning of the 70s, nifurtimox and benznidazole were introduced for clinical treatment, but results showed a great variability and there is still a controversy about their use for chronic cases. After the introduction of these nitroheterocycles only a few compounds were assayed in chagasic patients. The great advances in vector control in the South Cone countries, and the demonstration of parasite in chronic patients indicated the urgency to discuss the etiologic treatment during this phase, reinforcing the need to find drugs with more efficacy and less toxicity. We also review potential targets in the parasite and present a survey about new classes of synthetic and natural compounds studied after 1992/1993, with which we intend to give to the reader a general view about experimental studies in the area of the chemotherapy of Chagas disease, complementing the previous papers of Brener (1979) and De Castro (1993).