Regulatory mechanisms and functions of MAP kinase signaling pathways
Regulatory mechanisms and functions of MAP kinase signaling pathways
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DOI：
10.1080/15216540600746393
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发表时间：
2006-05-01
期刊：
影响因子：
4.6
通讯作者：
Nishida, Eisuke
中科院分区：
文献类型：
--
作者：
Imajo, Masamichi;Tsuchiya, Yoshiki;Nishida, Eisuke
丝裂原活化蛋白激酶（MAPK）通路在控制多种细胞功能中起着重要作用。它们受到几种机制的精细调控，包括其组分的支架化，以及MAPK的磷酸化/去磷酸化和区室化。许多分子已被确定为参与这些机制的调节剂。它们调节MAPK信号传导的幅度和特异性，从而调节各种各样的信号输出。最近的研究发现了MAPK信号通路的新功能。越来越清楚的是，MAPK途径的严格调节是其在许多生物过程中的多种功能的基础。
Mitogen-activated protein kinase (MAPK) pathways play central roles in controlling diverse cellular functions. They are finely regulated by several mechanisms, including scaffolding of their components, and phosphorylation/dephosphorylation and compartmentalization of MAPKs. A number of molecules have been identified as regulators involved in these mechanisms. They modulate the magnitude and the specificity of MAPK signaling, and thereby regulate the wide variety of signaling outputs. Recent studies have identified novel functions of the MAPK signaling pathways. It is becoming clear that strict regulation of the MAPK pathways underlies their manifold functions in numerous biological processes.