Prevalence of and risk factors for antibody to hepatitis E virus seroreactivity among blood donors in northern California
Prevalence of and risk factors for antibody to hepatitis E virus seroreactivity among blood donors in northern California
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DOI：
10.1086/514037
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发表时间：
1997-07-01
影响因子：
6.4
通讯作者：
Holland, PV
中科院分区：
文献类型：
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作者：
Mast, EE;Kuramoto, IK;Holland, PV
为了评估戊型肝炎病毒抗体（抗hev）的血清反应性，对5000名美国献血者进行了两种免疫检测：一种是镶嵌蛋白检测（MPr-EIA），另一种是重组蛋白检测（rp - eia）。MPr-EIA血清反应59例（1.2%），RPr-EIA血清反应70例（1.4%），两者总体一致性为98.5% (4925/5000)；两种检测反应性血清的一致性仅为27%（27/102）。在一项病例对照研究中，血清反应者比血清阴性者更有可能前往HEV流行国家旅行（MPr-EIA的比值比[OR] = 4.3, P < .001； rp - eia的比值比[OR] = 2.5, P = .005），但31%的MPr-EIA抗HEV反应者和38%的rp - eia抗HEV反应者没有国际旅行史，这些发现表明，前往HEV流行地区的旅行者可能会感染亚临床HEV感染。没有国际旅行史的人血清抗戊肝病毒反应的意义有待确定。
To evaluate antibody to hepatitis E virus (anti-HEV) seroreactivity, 5000 US blood donors were tested for anti-HEV by two EIAs: a mosaic protein assay (MPr-EIA) and a recombinant protein assay (RPr-EIA). Overall, 59 (1.2%) were seroreactive by MPr-EIA and 70 (1.4%) were seroreactive by RPr-EIA, The overall concordance between tests was 98.5% (4925/5000); the concordance among reactive sera by either test was only 27% (27/102). In a case-control study, seroreactive persons were more likely than seronegative persons to have traveled to countries in which HEV is endemic (odds ratio [OR] for MPr-EIA = 4.3, P < .001; OR for RPr-EIA = 2.5, P = .005), but 31% of MPr-EIA anti-HEV-reactive persons and 38% of RPr-EIA anti-HEV-reactive persons had no history of international travel, These findings suggest that travelers to regions in which HEV is endemic can acquire subclinical HEV infection. The significance of anti-HEV seroreactivity among persons without an international travel history needs to be determined.