White matter hyperintensity shape is associated with long-term dementia risk.
White matter hyperintensity shape is associated with long-term dementia risk.
复制标题
白质高信号形状与长期痴呆风险相关。
DOI：
10.1002/alz.13345
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
deBresser,Jeroen
中科院分区：
文献类型：
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作者：
Keller,JasminAnnica;Sigurdsson,Sigurdur;Klaassen,Kelly;Hirschler,Lydiane;vanBuchem,MarkA;Launer,LenoreJ;vanOsch,MatthiasJP;Gudnason,Vilmundur;deBresser,Jeroen
[目的]探讨社区老年人脑白质高强度(WMH)形态和体积与长期痴呆风险的关系。方法对1000名年龄基因/环境易感性(AGEs)-雷克雅未克研究的受试者进行了基线1.5T脑磁共振成像，并对痴呆症进行了随访(平均随访：9.9±26.6年)。较高的凹度指数1.43(1.32~1.54)，较高的分维1.45(1.32~1.58)，P<；1.001)，较高的WMH总容量(1.68(1.54~1.87)，P<；等001)，较高的脑室周围/汇合WMH体积(1.71(1.55~1.89)，P<；较高的深层WMH容量(1.17(1.08至1.27)，p<；2.001)与长期痴呆风险增加相关。DISCUSSIONWMH形状标记物未来可能在确定患者预后方面有用，并可能有助于社区老年人未来预防性治疗的患者选择。
INTRODUCTIONWe aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long‐term dementia risk in community‐dwelling older adults.METHODSThree thousand seventy‐seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)‐Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow‐up: 9.9 ± 2.6 years).RESULTSMore irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52),p< .001) and convexity 1.38 (1.28 to 1.49),p< .001); higher concavity index 1.43 (1.32 to 1.54),p< .001) and fractal dimension 1.45 (1.32 to 1.58),p< .001)), higher total WMH volume (1.68 (1.54 to 1.87),p< .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89),p< .001), and higher deep WMH volume (1.17 (1.08 to 1.27),p< .001) were associated with an increased long‐term dementia risk.DISCUSSIONWMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community‐dwelling older adults.