A battery-driven, low-field NMR unit for thermally and hyperpolarized samples
A battery-driven, low-field NMR unit for thermally and hyperpolarized samples
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DOI：
10.1007/s10334-013-0366-7
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发表时间：
2013-10-01
影响因子：
2.3
通讯作者：
Hoevener, Jan-Bernd
中科院分区：
文献类型：
--
作者：
Borowiak, Robert;Schwaderlapp, Niels;Hoevener, Jan-Bernd
多核低场核磁共振装置的设计，其可变场强< 6 mT，提供精确的自旋操纵和足够的灵敏度，用于直接检测处于热平衡的样品，以辅助仲氢基超极化实验。一种连接到鞍形发射和螺线管接收线圈的数字设备，其能够以高达10（6）个样本/s的速度激励和检测MR信号，通过灵活的脉冲编程软件进行控制。在1.8和5.7 mT下的热极化样品的磁化在单次采集中被检测到，SNR为千分之10（1）和千分之10（2）线宽分别为42和32 Hz。核自旋通过脉冲被操纵到+/-1A度的不确定性，这些脉冲可以以任意组合排列。作为示范，标准的实验测量的热极化样品的弛豫参数进行了实施。我们成功地实现了在1.8和5.5mT下的热和超极化H-1-MR信号的一次采集和精确的自旋操作。
The design of a multinuclear low-field NMR unit with variable field strength < 6 mT providing accurate spin manipulations and sufficient sensitivity for direct detection of samples in thermal equilibrium to aid parahydrogen-based hyperpolarization experiments.An optimized, resistive magnet connected to a battery or wall-power driven current source was constructed to provide a magnetic field < 6 mT. A digital device connected to a saddle-shaped transmit- and solenoid receive-coil enabled MR signal excitation and detection with up to 10(6) samples/s, controlled by a flexible pulse-programming software.The magnetization of thermally polarized samples at 1.8 and 5.7 mT is detected in a single acquisition with a SNR a parts per thousand 10(1) and a parts per thousand 10(2) and a line width of 42 and 32 Hz, respectively. Nuclear spins are manipulated to an uncertainty of +/- 1A degrees by means of pulses, which can be arranged in an arbitrary combination. As a demonstration, standard experiments for the measurement of relaxation parameters of thermally polarized samples were implemented. The detection of much stronger hyperpolarized signal was exemplified employing parahydrogen.Direct detection of thermal and hyperpolarized H-1-MR signal in a single acquisition and accurate spin manipulations at 1.8 and 5.5 mT were successfully demonstrated.