Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects
Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects
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DOI：
10.1111/j.1365-2036.2007.03367.x
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发表时间：
2007-07-15
影响因子：
7.6
通讯作者：
Haruma, K.
中科院分区：
文献类型：
--
作者：
Miwa, H.;Nakajima, K.;Haruma, K.
目的酸和消化不良症状之间的关系尚未完全understood.Aim探讨消化不良症状的类型和严重程度引起的直接酸注入胃的日本健康subjects.Methods这是一个多中心，交叉，随机，双盲研究27名健康受试者（平均年龄27）。每例禁食受试者接受两次试验，分别输注150 mL 0.1 mol/L盐酸（15 mL/min，持续10 min）和相同体积的纯水。症状的类型和严重程度进行了评估，由10厘米的视觉模拟量表管理，每2分钟至30分钟。结果各种症状后，报告酸和水输注。与水输注相比，酸输注后大多数症状更严重（酸与水：不适1.8 +/- 0.4 vs. 0.5 +/- 0.1，疼痛0.6 +/- 0.3 vs. 0.1 +/- 0.1，反流1.0 +/- 0.3对0.3 +/- 0.1和饱腹感1.1 +/- 0.4对0.2 +/- 0.1）。曲线下面积为动力障碍样症状（沉重的感觉在胃，腹胀，恶心或感觉恶心，打嗝）显着较高的酸输液，症状持续后输液的酸。结论酸诱导胃动力障碍样主要消化不良症状在日本健康对照组，表现出可能的重要性，酸的症状产生。
Objective The relationship between acid and dyspeptic symptoms has not been fully understood.Aim To investigate the type and severity of dyspeptic symptoms induced by direct acid infusion into the stomach of Japanese healthy subjects.Methods This was a multi-centre, cross-over, randomized, double-blind study in 27 healthy subjects ( mean age 27). Each fasted subject received two tests with 150 mL of 0.1 mol/L hydrochloric acid infusion (15 mL/min for 10 min) and the same volume of pure water infusion. The type and severity of symptoms were assessed by a 10 cm visual analogue scale administered every 2 min up to 30 min.Results Various symptoms were reported after both acid and water infusions. Most of the symptoms were more severe after acid infusion compared with water infusion (acid vs. water: discomfort 1.8 +/- 0.4 vs. 0.5 +/- 0.1, pain 0.6 +/- 0.3 vs. 0.1 +/- 0.1, reflux 1.0 +/- 0.3 vs. 0.3 +/- 0.1 and satiety 1.1 +/- 0.4 vs. 0.2 +/- 0.1). The area under curve for dysmotility like symptoms ( heavy feeling in the stomach, bloating, nausea or feeling sick, and belching) was significantly higher in acid infusion, and symptoms continued after infusion of the acid.Conclusion Acid induced into stomach induced dysmotility-like predominant dyspeptic symptoms in Japanese healthy control subjects, demonstrating the possible importance of acid in symptom generation.