7 Tesla MPRAGE Imaging of the Intracranial Arterial Vasculature: Nonenhanced versus Contrast-Enhanced
7 Tesla MPRAGE Imaging of the Intracranial Arterial Vasculature: Nonenhanced versus Contrast-Enhanced
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DOI：
10.1016/j.acra.2012.12.012
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发表时间：
2013-05-01
影响因子：
4.8
通讯作者：
Schlamann, Marc
中科院分区：
文献类型：
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作者：
Umutlu, Lale;Theysohn, Nina;Schlamann, Marc
目的：比较7特斯拉(T)快速梯度回波(MPRAGE)快速梯度回波(MPRAGE)平扫和增强扫描对颅内动脉血管的显示情况。材料与方法：16例受试者在配备32通道发射/接收磁头线圈的7 T全身磁共振系统(Magnetom 7T)上检查。分别于注射0.1 mm ol/kg体重的加多布特洛尔前后行MPRAGE成像。对于定性分析，在非增强和对比度增强的数据集中使用5分(5=优到1=非诊断性)来评估颅内动脉的描绘、整体图像质量和图像损伤。此外，还获得了平扫和增强后大脑中动脉与周围灰质的对比度(CR)。结果：平扫MPRAGE成像能很好地显示前循环中央血管节段(平均前循环4.6条)，对后循环血管(平均后循环3.9条)有中高质量的评价。除了颈内动脉的海绵状血管段外，在增强对比数据集中的所有评估节段的血管轮廓都得到了改善。定量分析显示M1节段的CR平均值有轻微的、不显著的增加(CRNONON增强0.67；CRCORASTER增强0.69)。结论：7T MPRAGE平扫对评估颅内动脉血管有很高的诊断价值，由于使用了造影剂，改善了对周围节段的评估。
Purpose: To intraindividually compare the delineation of intracranial arterial vasculature in nonenhanced versus contrast-enhanced magnetization prepared rapid gradient echo (MPRAGE) imaging at 7 Tesla (T).Materials and Methods: Sixteen subjects were examined on a 7 T whole-body magnetic resonance system (Magnetom 7T) equipped with a 32-channel transmit/receive head coil. MPRAGE imaging was performed pre- and postcontrast after the application of 0.1 mmol/kg bodyweight gadobutrol. For qualitative analysis, the delineation of the intracranial arteries, overall image quality, and image impairment were assessed in the nonenhanced and contrast-enhanced datasets using a 5-point scale (5 = excellent to 1 = nondiagnostic). Additionally, contrast ratios (CR) of the middle cerebral artery in correlation to surrounding gray matter in nonenhanced and postcontrast images were obtained. For statistical analysis a Wilcoxon signed-rank test was applied.Results: Nonenhanced MPRAGE imaging offered an excellent delineation of the central vessel segments of the anterior circulation (mean anterior circulation 4.6) and a moderate- to high-quality assessment of the vessels of the posterior circulation (mean posterior circulation 3.9). Vessel delineation was improved in all assessed segments in the contrast-enhanced datasets, except for the cavernous segment of the internal carotid artery. Quantitative analysis revealed a mild, nonsignificant increase in CR mean values of the M1 segment (CRnonenhanced 0.67; CRcontrast-enhanced 0.69).Conclusion: Our results demonstrate the high diagnostic value of nonenhanced 7 T MPRAGE imaging for the assessment of the intracranial arterial vasculature, with improved assessment of the peripheral segments because of the application of a contrast agent.