Changes of somatosensory evoked potentials during writing with the dominant and non-dominant hands
Changes of somatosensory evoked potentials during writing with the dominant and non-dominant hands
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DOI：
10.1016/s0006-8993(99)01443-2
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发表时间：
1999-06-26
期刊：
影响因子：
2.9
通讯作者：
Kakigi, R
中科院分区：
文献类型：
--
作者：
Hoshiyama, M;Kakigi, R
由于进行困难的非熟练动作需要密切注意和特别努力，因此，这些动作背后的特定大脑活动可以预期发生在初级感觉-运动皮质(SI和MI)。在这项研究中，我们通过分析12名右利手和8名左撇子正常受试者的优势手和非优势手在书写过程中电刺激正中神经时的躯体感觉诱发电位(SEP)的差异来关注这种活动。在书写过程中，通过交替刺激左右正中神经，记录两个半球的SEP。在优势手写时，中潜伏期SEP成分，即顶叶P25、N33和额叶N30，仅在书写手对侧大脑半球显著减弱，与传统的门控效应相对应。在非优势手书写过程中，不仅记录于书写手对侧大脑半球的成分显著减弱，而且记录于书写手同侧半球的成分也显著减弱。此外，书写手对侧大脑半球的N20也明显减弱。右撇子和左撇子受试者之间的衰减没有显著差异。结果表明，电刺激后的信号与非优势手书写相关的感觉皮层活动在两个大脑半球都有特异性的相互作用，而在优势手书写时，这种作用仅在与书写手对侧的大脑半球被识别。我们推测，与优势手相比，在非优势手的非熟练运动中，躯体感觉皮层更活跃，从而与施加的刺激相互作用。(C)1999 Elsevier Science B.V.保留所有权利。
Since close attention and special effort are necessary to perform difficult unskilled movements, particular brain activities underlying such movements could be expected to take place in the primary sensori-motor cortices (SI and MI). In this study we focused on such activities by analyzing the difference in the somatosensory evoked potential (SEP) in presence to the electrical stimulation of the median nerve during writing using the dominant and non-dominant hands in twelve right-handed and eight left-handed normal subjects. By alternately stimulating the right and left median nerves during the writing with either hand, SEPs were recorded from both hemispheres. During the dominant hand writing, the middle latency SEP components, i.e., parietal P25 and N33 and frontal N30, were significantly attenuated only in the hemisphere contralateral to the writing hand, corresponding to the conventional gating effect. During the non-dominant hand writing, not only those components recorded from the hemisphere contralateral to the writing hand, but also those from the hemisphere ipsilateral to the writing hand were significantly attenuated. In addition, N20 in the hemisphere contralateral to the writing hand was also significantly attenuated. There was no significant difference in the attenuation between the right-handed and left-handed subjects. The results indicated that the specific interaction between the signals after electrical stimulation and the sensory cortical activities related to the writing using the non-dominant hand occurred in both hemispheres, while it was recognized only in the hemisphere contralateral to the writing hand during the dominant hand writing. We speculate that the somatosensory cortex was more activated and thus interacted with the applied stimulation during the unskilled movement of the non-dominant hand compared to the movement of the dominant hand. (C) 1999 Elsevier Science B.V. All rights reserved.