Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants.
Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants.
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DOI：
10.1203/pdr.0b013e3181da75c1
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发表时间：
2010-06
影响因子：
3.6
通讯作者：
Barasch JM
中科院分区：
文献类型：
--
作者：
Parravicini E;Nemerofsky SL;Michelson KA;Huynh TK;Sise ME;Bateman DA;Lorenz JM;Barasch JM
对极低出生体重儿（VLBW）败血症的早期识别的需要导致了对可靠生物标志物的研究。本研究旨在确定尿中性粒细胞明胶酶相关脂质运载蛋白（uNGAL）是否在培养阳性脓毒症中升高，如果是，则在怀疑脓毒症时升高。这是一项对91名VLBW婴儿的前瞻性研究，每天收集他们的尿液进行uNGAL分析。在65例疑似脓毒症中，确定了四组：A）培养阳性脓毒症; B）单一培养阳性S。C）和D）分别用抗生素处理≥ 7天和< 7天的阴性培养物。估计各组uNGAL的每日平均值以进行比较。与健康VLBW婴儿的平均值（6.5 ng/ml）以及与B、C和D组的平均值相比，A组的平均uNGAL（179 ng/ml）在抽取血液培养物的当天（第0天）显著升高（p<0.05）。在A组中，当与培养前一天相比时，在第0天和每天持续5天的平均uNGAL显著升高（p <0.05至< 0.005）。uNGAL有望成为VLBW婴儿败血症培养阳性的早期标志物。
Need for the early identification of sepsis in very low birth weight (VLBW) infants has led to the search for reliable biomarkers. This study aims to determine whether urinary neutrophil gelatinase-associated lipocalin (uNGAL) rises in culture-positive sepsis and, if so, is elevated at the time sepsis is suspected. This is a prospective study of 91 VLBW infants whose urine was collected daily for uNGAL analysis. In 65 episodes of suspected sepsis, four groups were identified: A) culture-positive sepsis; B) single culture positive for S. epidermidis; C) and D) negative culture with antibiotic treatment for ≥ 7 days and < 7 days, respectively. Daily means of uNGAL of each group were estimated for comparison. Mean uNGAL in group A (179 ng/ml) was significantly elevated on the day blood culture was drawn (day 0) compared to the mean of healthy VLBW infants (6.5 ng/ml), and to the means in groups B, C and D (p<0.05). In group A mean uNGAL was significantly elevated on day 0 and daily for five days when compared with that of the day prior to culture (p <0.05 to < 0.005). uNGAL shows promise as an early marker for culture-positive sepsis in VLBW infants.