Serum leptin and loss of control eating in children and adolescents
Serum leptin and loss of control eating in children and adolescents
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DOI：
10.1038/ijo.2013.126
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发表时间：
2014-03-01
影响因子：
4.9
通讯作者：
Yanovski, J. A.
中科院分区：
文献类型：
--
作者：
Miller, R.;Tanofsky-Kraff, M.;Yanovski, J. A.
背景技术背景：这两个不足和抵抗脂肪细胞衍生的激素瘦素的行动促进饥饿，增加食物摄入量和更大的体重。一些研究表明，与那些没有暴饮暴食的人相比，报告暴饮暴食的成年人血清瘦素增加，即使在调整了暴饮暴食者的肥胖特征之后。儿童暴饮暴食或饮食失控是体重过度增加的潜在危险因素，并可能预测代谢异常的发展，但儿童暴饮暴食是否与更高的瘦素相关尚不清楚。因此，我们研究了瘦素和饮食在儿科coherent.METHODS：一个方便的样本506瘦和肥胖的青年（7-18岁），从华盛顿，DC及其郊区招募。空腹过夜后收集血清瘦素。通过双能X线吸收法或空气置换体积描记法测量肥胖。结果：瘦素与脂肪量密切相关（r = 0.79，P
BACKGROUND: Both insufficiency and resistance to the actions of the adipocyte-derived hormone leptin promote hunger, increased food intake and greater body weight. Some studies suggest that adults reporting binge eating have increased serum leptin compared with those without binge eating, even after adjusting for the greater adiposity that characterizes binge eaters. Pediatric binge or loss of control (LOC) eating are prospective risk factors for excessive weight gain and may predict development of metabolic abnormalities, but whether LOC eating is associated with higher leptin among children is unknown. We therefore examined leptin and LOC eating in a pediatric cohort.METHODS: A convenience sample of 506 lean and obese youth (7-18 years) was recruited from Washington, DC and its suburbs. Serum leptin was collected after an overnight fast. Adiposity was measured by dual-energy X-ray absorptiometry or air displacement plethysmography. LOC eating was assessed by interview methodology.RESULTS: Leptin was strongly associated with fat mass (r = 0.79, P