A comparison of deterministic and stochastic simulations of neuronal vesicle release models.
A comparison of deterministic and stochastic simulations of neuronal vesicle release models.
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DOI：
10.1088/1478-3975/7/2/026008
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发表时间：
2010-05-26
期刊：
影响因子：
2
通讯作者：
Rappel WJ
中科院分区：
文献类型：
--
作者：
Modchang C;Nadkarni S;Bartol TM;Triampo W;Sejnowski TJ;Levine H;Rappel WJ
We study the calcium-induced vesicle release into the synaptic cleft using a deterministic algorithm and MCell, a Monte Carlo algorithm that tracks individual molecules. We compare the average vesicle release probability obtained using both algorithms and investigate the effect of the three main sources of noise: diffusion, sensor kinetics and fluctuations from the voltage-dependent calcium channels (VDCCs). We find that the stochastic opening kinetics of the VDCCs are the main contributors to differences in the release probability. Our results show that the deterministic calculations lead to reliable results, with an error of less than 20%, when the sensor is located at least 50 nm from the VDCCs, corresponding to microdomain signaling. For smaller distances, i.e. nanodomain signaling, the error becomes larger and a stochastic algorithm is necessary.
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影响因子：
2
作者：
Erban, Radek;Chapman, S. Jonathan
通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.162041399
发表时间：
2002-10-01
影响因子：
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作者：
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通讯作者：
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