INTERLEUKIN-6 PRODUCTION IN THE CENTRAL-NERVOUS-SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
INTERLEUKIN-6 PRODUCTION IN THE CENTRAL-NERVOUS-SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
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DOI：
10.1002/eji.1830200134
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发表时间：
1990-01-01
影响因子：
5.4
通讯作者：
BILLIAU, A
中科院分区：
文献类型：
--
作者：
GIJBELS, K;VANDAMME, J;BILLIAU, A
白介素6(IL6)是一种主要的炎症相关细胞因子。血清或组织中IL6水平的升高已被报道出现在几种人类疾病中，包括中枢神经系统(CNS)感染，但在非感染性CNS炎症中未见，如多发性硬化症。在研究实验性自身免疫性脑脊髓炎(EAE)作为中枢神经系统自身免疫性炎症的动物模型时，我们发现患有致死性疾病的小鼠中枢神经系统中IL6水平升高。脾和血清中IL-6水平未见明显升高。这些发现表明，在EAE期间，中枢神经系统局部产生了IL-6，并首次证明了IL-6在非传染性中枢神经系统炎症性疾病中的产生。
Interleukin 6 (IL6) is one of the major inflammation-associated cytokines. Elevated serum or tissue levels of IL6 have been reported to occur in several human diseases, including infections of the central nervous system (CNS), but not in non-infectious CNS inflammation, e.g. multiple sclerosis. While studying experimental autoimmune encephalomyelitis (EAE) as an animal model for autoimmune inflammation of the CNS, we found increased IL6 levels in the CNS of mice suffering from a lethal form of the disease. IL6 levels in the spleens and sera were not significantly increased. These findings are indicative of local production of IL6 in the CNS during EAE, and represent the first demonstration of IL 6 production in non-infectious CNS inflammatory disease.