Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients
Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients
复制标题
DOI：
10.3390/ijms17101637
复制
发表时间：
2016-10-01
影响因子：
5.6
通讯作者：
Hattori, Toshio
中科院分区：
文献类型：
--
作者：
Chagan-Yasutan, Haorile;Chen, Yue;Hattori, Toshio
钩端螺旋体病是一种人畜共患疾病，其严重形式通常伴有肾功能障碍。在本研究中，研究了尿标志物对疾病严重程度的潜在预测。对菲律宾圣拉扎罗医院135例有或无钩端螺旋体病患者的尿样进行了分析。将尿液中的防御素α 1（uDA 1）水平与中性粒细胞明胶酶相关脂质运载蛋白（uNGAL）和N-乙酰-β-D-葡萄糖苷酶（uNAG）水平进行比较。血清肌酐（Cr）被用作肾损伤的标志物。uDA 1/Cr、uNGAL/Cr和uNAG/Cr在钩体病患者和非钩体病患者中的阳性率分别为46%、90%和80%和69%、70%和70%。钩体病患者uDA 1/Cr、uNGAL/Cr和uNAG/Cr与血清Cr的相关性分别为r = 0.3（p < 0.01）、r = 0.29（p < 0.01）和r = 0.02（p = 0.81）。钩体病患者uDA 1/Cr与uNGAL/Cr（r = 0.49，p < 0.01）和uNAG/Cr（r = 0.47，p < 0.0001）相关。这些结果表明，uDA 1，uNGAL和uNAG在钩端螺旋体病患者中升高，并反映了各种类型的肾损害。uDA 1和uNGAL与血清Cr水平相关，可用于监测钩体病患者的肾损伤。
Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin alpha 1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) and N-acetyl-beta-D-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr were r = 0.3 (p < 0.01), r = 0.29 (p < 0.01), and r = 0.02 (p = 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels (r = 0.49, p < 0.01) and uNAG/Cr levels (r = 0.47, p < 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level.