TRANSFORMATION AND TUMOR PROGRESSION ARE FREQUENTLY ASSOCIATED WITH EXPRESSION OF THE ALPHA(3)/BETA(1) HETERODIMER IN SOLID TUMORS
TRANSFORMATION AND TUMOR PROGRESSION ARE FREQUENTLY ASSOCIATED WITH EXPRESSION OF THE ALPHA(3)/BETA(1) HETERODIMER IN SOLID TUMORS
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DOI：
10.1002/ijc.2910580405
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发表时间：
1994-08-15
影响因子：
6.4
通讯作者：
NATALI, PG
中科院分区：
文献类型：
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作者：
BARTOLAZZI, A;CERBONI, C;NATALI, PG
肿瘤细胞与细胞外基质（ECM）相互作用的能力是由多种受体分子在功能上介导的，其中整合素是一个很有特征的介质家族。在这项研究中，我们用免疫组织化学方法研究了多种人类实体恶性肿瘤中ECM成分的α (3)/ β(1)混杂受体的体内表达。尽管该受体的分布模式似乎发生了变化，但其表达在原发（76%）和转移（82%）肿瘤中保持较高比例。此外，对α (3)/ β(1)及其配体在若干不同组织型肿瘤中的比较免疫组织化学评价表明，该整合素的表达与肿瘤细胞巢周围或上皮-基质界面上至少一种配体的存在相关。本研究中显示的α (3)/ β(1)的高度保守表达表明，该受体可能在原发和转移部位的肿瘤生长中发挥作用。(C) 1994 Wiley-Liss, Inc。
The ability of tumor cells to interact with the extracellular matrix (ECM) is functionally mediated by a variety of receptor molecules among which the integrins are a well-characterized family of mediators. In this study we have investigated immunohistochemically the in vivo expression of the alpha(3)/beta(1) promiscuous receptor for ECM constituents in a variety of human solid malignancies. Although the receptor appears to undergo changes in distribution patterns, its expression is maintained in a high percentage of primary (76%) and metastatic (82%) tumors. Furthermore, the comparative immunohistochemical evaluation of alpha(3)/beta(1) and its ligands, in a selected number of tumors of different histotypes, demonstrated that the expression of this integrin correlated with the presence of at least one ligand, either around nests of neoplastic cells or at the epithelial-stromal interface. The highly conserved expression of alpha(3)/beta(1) shown in this study suggests that this receptor may play a role in tumor growth at the primary as well as the metastatic site. (C) 1994 Wiley-Liss, Inc.