Novel splice variants of IL-33: differential expression in normal and transformed cells.
Novel splice variants of IL-33: differential expression in normal and transformed cells.
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DOI：
10.1038/jid.2012.180
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发表时间：
2012-11
期刊：
影响因子：
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通讯作者：
H. Tsuda;M. Komine;M. Karakawa;T. Etoh;S. Tominaga;M. Ohtsuki
中科院分区：
文献类型：
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作者：
H. Tsuda;M. Komine;M. Karakawa;T. Etoh;S. Tominaga;M. Ohtsuki
IL-33是IL-1家族中新发现的成员，在多种器官的上皮细胞和内皮细胞中组成型表达（Moussion等，2008）。 IL-33 对于 T 辅助细胞 2 (Th2) 免疫反应很重要，因为它的受体 ST2L 在 Th2 淋巴细胞、嗜碱性粒细胞、嗜酸性粒细胞和肥大细胞上表达 (Schmitz et al., 2005)。它也可能独立于免疫反应而发挥作用（Sanada et al., 2007）。 IL-33通常存在于细胞核中，以原形式IL-33（pro-IL-33）的形式产生，并在从细胞分泌时被消化成具有较低分子量的成熟形式。成熟的 IL-33 最初被认为是活性形式（Schmitz 等，2005）。然而，最近的报告表明，IL-33 的活性前体被消化成无活性的成熟形式（Cayrol 和 Girard，2009）。
IL-33 is a newly discovered member of the IL-1 family and is constitutively expressed in the epithelial and endothelial cells of various organs (Moussion et al., 2008). IL-33 is important to the T helper 2 (Th2) immune reaction because its receptor, ST2L, is expressed on Th2 lymphocytes, basophils, eosinophils, and mast cells (Schmitz et al., 2005). It may also function independently of the immune reaction (Sanada et al., 2007). IL-33 is usually found in the nucleus, produced as pro-form IL-33 (pro-IL-33), and is digested into a mature form with a lower molecular weight when it is secreted from the cells. Mature IL-33 was first thought to be the active form (Schmitz et al., 2005). However, recent reports have shown that the active pro-form of IL-33 is digested into an inactive mature form (Cayrol and Girard, 2009).