In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry.
In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry.
复制标题
DOI：
10.1158/0008-5472.can-11-4027
复制
发表时间：
2012-06-01
期刊：
影响因子：
11.2
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Garcia-Uribe A;Zou J;Duvic M;Cho-Vega JH;Prieto VG;Wang LV
皮肤癌的早期发现和治疗可以显著改善患者的预后。然而，目前的诊断标准需要活检和组织病理学检查，这对于具有许多早期病变的患者来说是相对侵入性的、昂贵的和困难的。在这里，我们展示了一个斜入射漫反射光谱（OIDRS）系统，可用于快速检测体内皮肤癌。该系统在临床条件下进行了测试，通过获得光谱的色素和非色素皮肤病变，包括黑色素瘤，不同阶段的发育不良痣和普通痣，通过标准的病理组织学标准进行验证。对于色素性黑色素瘤的诊断，所获得的数据对于盲法测试集达到90%的灵敏度和特异性。在第二次分析中，我们证明了这种光谱系统也可以区分非色素性基底细胞癌或鳞状细胞癌与非癌性皮肤异常，如光化性角化病和脂溢性角化病，达到92%的灵敏度和特异性。总之，我们的研究结果确定了斜入射漫反射光谱法如何在临床上以准确和自动化的方式更快速，更容易地诊断皮肤癌。
Early detection and treatment of skin cancer can significantly improve patient outcome. However, present standards for diagnosis require biopsy and histopathologic examinations that is relatively invasive, expensive and difficult for patients with many early stage lesions. Here we show an oblique incidence diffuse reflectance spectroscopic (OIDRS) system that can be used for rapid skin cancer detection in vivo. This system was tested under clinical conditions by obtaining spectra from pigmented and non-pigmented skin lesions, including melanomas, differently staged dysplastic nevi and common nevi that were validated by standard patho-histological criteria. For diagnosis of pigmented melanoma, the data obtained achieved 90% sensitivity and specificity for a blinded test set. In a second analysis, we demonstrated that this spectroscopy system can also differentiate non-pigmented basal cell or squamous cell carcinomas from non-cancerous skin abnormalities such as actinic keratoses and seborrheic keratoses, achieving 92% sensitivity and specificity. Taken together, our findings establish how oblique incidence diffuse reflectance spectrometry can be used to more rapidly and easily diagnose skin cancer in an accurate and automated manner in the clinic.