No disease in the brain of a 115-year-old woman
No disease in the brain of a 115-year-old woman
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DOI：
10.1016/j.neurobiolaging.2008.04.010
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发表时间：
2008-08-01
影响因子：
4.2
通讯作者：
Holstege, Gert
中科院分区：
文献类型：
--
作者：
den Dunnen, Wilfred F. A.;Brouwer, Wiebo H.;Holstege, Gert
高质量生活的持续时间有限制吗？人脑的健康生活有极限吗？我们有机会评估了一位112-113岁女性的表现，并在115岁去世后立即对她的身体进行了全面的病理检查。心理测试显示，她的总体表现高于60-75岁健康成年人的平均水平。病理观察显示，全身几乎没有动脉粥样硬化的变化。在大脑中，几乎没有发现β-淀粉样斑块或血管改变，只有轻微的过度磷酸化的tau蛋白积聚，呈Braak-2期。蓝斑神经元的数量与60-80岁健康人脑中的神经元数量相一致。我们的观察表明，人类认知功能的极限远远超出了大多数人目前享有的范围，大脑疾病，即使是在超级百岁老人中，也不是不可避免的。(C)2008年，爱思唯尔公司出版。
Are there limits to the duration of high quality of life? Are there limits to healthy life for a human brain? We have had the opportunity to evaluate the performance of a 112-113-year-old woman and perform full pathological examination of her body immediately after death at the age of 115. The psychological tests revealed that her general performance was above average of healthy adults of 60-75 years. The pathological observations revealed almost no atherosclerotic changes throughout the body. In the brain almost no beta-amyloid plaques or vascular changes were found and only slight accumulation of hyperphosphorylated tau protein with a Braak-stage 2. Counts of the number of locus coeruleus neurons corresponded with the number of neurons found in the brains of healthy people of 60-80 years old. Our observations indicate that the limits of human cognitive function extends far beyond the range that is currently enjoyed by most individuals and that brain disease, even in supercentanarians, is not inevitable. (c) 2008 Published by Elsevier Inc.