Tpeak-Tend interval as an index of global dispersion of ventricular repolarization:: Evaluations using monophasic action potential mapping of the epi- and endocardium in swine
Tpeak-Tend interval as an index of global dispersion of ventricular repolarization:: Evaluations using monophasic action potential mapping of the epi- and endocardium in swine
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DOI：
10.1007/s10840-005-4592-4
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发表时间：
2005-11-01
影响因子：
1.8
通讯作者：
Yuan, SW
中科院分区：
文献类型：
--
作者：
Xia, YL;Liang, YC;Yuan, SW
从T波峰期到T波末期的心电图间期(T-峰-T-END)已被用作评价跨室壁复极离散度(DVR)的指标。方法：用Carto标测系统记录10头猪左室51+/-10个心外膜和+/-9个心内膜部位和2个右室心外膜41+/-4个和53+/-2个心内膜部位的单相动作电位。测量心外膜和心内膜复极末期时间，计算心外膜复极末期离散度(DVR-EPI)、心内膜复极末期离散度(DVR-ENDO)和心内膜复极末期离散度(DVR-TOTAL)。结果：最大T峰-T末间期(57+/-7ms)与DVR-TOT值(58+/-11ms，p>；0.05)一致，与DVR-TOTAL呈显著正相关(r=0.64，p<；0.05)。然而，II导联(41+/-6ms)和V-5导联(43+/-5ms)的平均T峰-T末间期(44+/-5ms)和T-峰-T-末间期(43+/-5ms)均明显小于DVR-TVT值，QT(峰)和QT(END)离散度(15+/-2ms比21+/-4ms)均明显小于DVR-TVT值。结论：最大T-峰-T-END间期可作为无创性评价整体DVR的指标。但不包括QT(峰)和QT(末)离散度，也不包括平均T-峰-T-末间期和单个导联的平均T-峰-T-末间期。
The ECG interval from the peak to the end of the T wave (T-peak-T-end) has been used as an index of transmural dispersion of ventricular repolarization (DVR). The correlation between the T-peak-T-end interval and the global DVR, however, has not been well-evaluated.Methods: Monophasic action potentials (MAPs) were recorded from 51 +/- 10 epicardial and 64 +/- 9 endocardial sites in the left ventricles of 10 pigs, and from 41 +/- 4 epicardial and 53 +/- 2 endocardial sites in the right ventricles of 2 of the 10 pigs using the CARTO mapping system. The end of repolarization times over the epi- and endocardium were measured, and the end of repolarization dispersions over the epicardium (DVR-epi), over the endocardium (DVR-endo) and over both (DVR-total) were calculated. The QT(peak), QT(end) and T-peak-T-end intervals as well as the QT(peak) and QT(end) dispersions were obtained from the simultaneously recorded 12-lead ECG.Results: The maximal T-peak-T-end intervals (57 +/- 7 ms) were consistent with the DVR-total (58 +/- 11 ms, p > 0.05), and significantly correlated with the DVR-total (r = 0.64, p < 0.05). However, the mean T-peak-T-end intervals (44 +/- 5 ms), and T-peak-T-end intervals from lead II (41 +/- 6 ms) and V-5 (43 +/- 5 ms) were all significantly smaller than and poorly correlated with the DVR-total, as were the QT(peak) and QT(end) dispersions (15 +/- 2 ms vs. 21 +/- 4 ms).Conclusion: The maximal T-peak-T-end interval may be used as a noninvasive estimate for the global DVR, but not the QT(peak) and QT(end) dispersions, nor the mean T-peak-T-end interval and that from a single lead.