Redox Signaling and Persistent Pulmonary Hypertension of the Newborn.
Redox Signaling and Persistent Pulmonary Hypertension of the Newborn.
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DOI：
10.1007/978-3-319-63245-2_16
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发表时间：
2017
影响因子：
--
通讯作者：
Megha Sharma;Adeleye J Afolayan
中科院分区：
文献类型：
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作者：
Megha Sharma;Adeleye J Afolayan
活性氧(ROS)是氧化还原信号分子，在调节内皮细胞功能、宿主防御、衰老和细胞适应等方面发挥重要作用。线粒体是肺循环中ROS的主要来源和氧化还原信号的重要来源。越来越多的证据表明，线粒体氧化应激增加和氧化还原敏感信号通路的异常在许多心肺疾病的发病机制中起着直接的作用，包括新生儿持续性肺动脉高压(PPHN)。本章重点介绍了内皮细胞中的氧化还原信号、抗氧化防御机制、细胞对氧化应激的反应以及它们在疾病发病机制中的作用。
Reactive oxygen species (ROS) are redox-signaling molecules that are critically involved in regulating endothelial cell functions, host defense, aging, and cellular adaptation. Mitochondria are the major sources of ROS and important sources of redox signaling in pulmonary circulation. It is becoming increasingly evident that increased mitochondrial oxidative stress and aberrant signaling through redox-sensitive pathways play a direct causative role in the pathogenesis of many cardiopulmonary disorders including persistent pulmonary hypertension of the newborn (PPHN). This chapter highlights redox signaling in endothelial cells, antioxidant defense mechanism, cell responses to oxidative stress, and their contributions to disease pathogenesis.