Serum Mannose-Binding Lectin Is a Strong Biomarker of Diabetic Retinopathy in Chinese Patients With Diabetes
Serum Mannose-Binding Lectin Is a Strong Biomarker of Diabetic Retinopathy in Chinese Patients With Diabetes
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DOI：
10.2337/dc14-1873
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发表时间：
2015-05-01
期刊：
影响因子：
16.2
通讯作者：
Lu, Yinying
中科院分区：
文献类型：
--
作者：
Geng, Peiliang;Ding, Yuanyuan;Lu, Yinying
甘露糖结合凝集素（MBL）引发的炎症和补体激活可能与糖尿病血管并发症的发病机制有关。我们调查了糖尿病患者和无糖尿病视网膜病变（DR）患者的血清MBL水平。研究设计和方法测定了348例糖尿病患者和100例健康对照者的血清MBL水平。MBL的预测值与糖尿病病程、hs-CRP和其他已知的预测因子进行比较。多因素分析显示糖尿病合并DR（P < 0.0001）和威胁视力的DR（VTDR; P <0.0001）患者入院时血清TTSMBL水平显著升高。校正常见指标后的多变量logistic回归分析显示，血清MBL水平3，385 g/L是DR（比值比[OR] 3.14，95%CI 1.77-5.57）和VTDR（OR 7.83，95%CI 3.35-18.31）的独立预测因子。MBL的受试者工作特征曲线下面积DR为0.81（95%CI 0.76-0.86），VTDR为0.84（95%CI 0.74-0.93）。结论MBL是中国人群DR的独立生物标志物，提示MBL可能在糖尿病DR并发症的发病机制中发挥作用。
OBJECTIVEInflammation and complement activation initiated by mannose-binding lectin (MBL) may be implicated in the pathogenesis of diabetic vascular complications. We investigated serum MBL levels in patients with diabetes with and without diabetic retinopathy (DR).RESEARCH DESIGN AND METHODSSerum MBL levels were determined in 348 patients with diabetes and in 100 healthy control subjects. The prediction value of MBL was compared with diabetes duration, hs-CRP, and other known predictors. Multivariate analyses were performed using logistic regression models.RESULTSMBL levels on admission were significantly increased in patients with diabetes with DR (P < 0.0001) and vision-threatening DR (VTDR; P < 0.0001). Multivariate logistic regression analysis adjusted for common indictors showed that serum MBL levels 3,385 g/L were an independent predictor of DR (odds ratio [OR] 3.14, 95% CI 1.77-5.57) and VTDR (OR 7.83, 95% CI 3.35-18.31). The area under the receiver operating characteristic curve of MBL was 0.81 (95% CI 0.76-0.86) for DR and 0.84 (95% CI 0.74-0.93) for VTDR.CONCLUSIONSThe current study demonstrated that MBL appears to be an independent biomarker for DR in the Chinese population, suggesting a possible role of MBL in the pathogenesis of DR complications in diabetes.